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BMC Nephrol:阜外医院学者发现,体脂比例可预测肾病风险

2018-03-02 文韬 中国循环杂志

阜外医院高润霖院士、王增武教授等研究发现,肥胖与慢性肾病风险升高相关,其中肥胖指标体脂百分比是识别慢性肾病的最佳预测因子。

阜外医院高润霖院士、王增武教授等研究发现,肥胖与慢性肾病风险升高相关,其中肥胖指标体脂百分比是识别慢性肾病的最佳预测因子。

研究者指出,鉴于肥胖是可改变的危险因素,慢性肾病患者应管理体重以预防慢性肾病进展,同时应筛查体脂百分比。

该研究中,慢性肾病总加权患病率为3.94%,男性和女性分别为3.62%和4.25%。

分析发现,5个肥胖指标,包括内脏脂肪指数、体脂百分比、体质指数、腰围和腰围身高比,均与估算肾小球滤过率呈显着的反相关。

其中,体脂百分比的ROC曲线下面积较其他四个肥胖指标明显更大。体脂百分比识别慢性肾病的约登指数(敏感性+特异性-1)也最高。

在对肥胖指标与慢性肾病风险的逻辑回归分析中,体脂百分比的粗OR也最高,男性和女性分别为1.819和2.268。校正混杂因素后,该OR仍然显着。

这项横断面研究采用分层多阶段随机抽样方法,在2012-2015年期间纳入中国各地区年龄≥35岁的近3万人。

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    2018-03-02 虈亣靌

    学习了感谢分享

    0

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    2018-03-02 131****1460

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