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J Hypertens:危险因素对高血压发生发展的综合影响

2018-10-14 xing.T MedSci原创

由此可见,年龄、静息心率、超重或肥胖、血脂异常、高尿酸血症、葡萄糖调节受损和eGFR受损与新发高血压的风险显著相关,并且它们合并时会导致风险累积。

近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,该研究旨在建立由七个危险因素:年龄、静息心率、超重或肥胖、血脂异常、高尿酸血症、葡萄糖调节受损和估计肾小球滤过率(eGFR)受损,组成的累积评分以评估新发高血压病的风险。

研究人员回顾性地对2365名无基线高血压的参与者进行了一项队列研究,他们在2011年至2016年期间参加了至少两次年度健康检查。研究人员将高血压定义为SBP为140mmHg或更低和/或DBP至少为90mmHg,根据2010年中国高血压管理指南。研究人员计算了包含所有七个危险因子的综合个体水平累积分数(无=0分;是=1分;总范围为0-7分)。Cox回归用于分析累积评分与高血压风险之间的关联。

该研究共有2305名参与者在中位随访期为3.6年期间发生高血压。与0分的参与者相比,2、3和至少4分患者发生高血压的风险比(95%置信区间)分别为1.61(1.29-2.02)、2.05(1.64-2.57)和2.77 (2.22-3.46)(趋势P<0.001)。在调整性别和基线血压后这种关联仍然存在。

由此可见,年龄、静息心率、超重或肥胖、血脂异常、高尿酸血症、葡萄糖调节受损和eGFR受损与新发高血压的风险显著相关,并且它们合并时会导致风险累积。

原始出处:

Huang, Yuli.et al. Combined impact of risk factors on the subsequent development of hypertension. Journal of Hypertension. 2018. https://journals.lww.com/jhypertension/Abstract/publishahead/Combined_impact_of_risk_factors_on_the_subsequent.97329.aspx

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    2019-08-04 feather89
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    2018-10-16 医者仁心5538

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