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Science:科学家找到了炎症“克星”

2017-05-15 Heather_z727 来宝网

【研究解密消炎的过程】炎症似乎是生活中不可避免的风险因素,由于炎症引起的慢性疾病更是数不胜数。在免疫系统中,巨噬细胞行为不仅可以抵御外来的侵入,还可以修复感染或者受损的组织。近期,《科学》杂志上发表了一篇来自耶鲁大学的研究,在研究报告中,科学家详细描述了巨噬细胞是如何完成这一不可能完成的任务。更加确定了巨噬细胞在处理炎症过程中不可或缺的积极作用。 长久以来,人们一直认为在感染初期,巨噬细

【研究解密消炎的过程】炎症似乎是生活中不可避免的风险因素,由于炎症引起的慢性疾病更是数不胜数。在免疫系统中,巨噬细胞行为不仅可以抵御外来的侵入,还可以修复感染或者受损的组织。近期,《科学》杂志上发表了一篇来自耶鲁大学的研究,在研究报告中,科学家详细描述了巨噬细胞是如何完成这一不可能完成的任务。更加确定了巨噬细胞在处理炎症过程中不可或缺的积极作用。
 
长久以来,人们一直认为在感染初期,巨噬细胞是根据细胞因子的指令完成修复感染的过程的。但是科学家提出疑问,细胞因子如IL-4和IL-13在修复伤口和感染时是如何运作的?
 
来自耶鲁大学神经学和药理学教授表示:“如果身体不想修复被感染的伤口,那么细胞因子指导完成修复就根本说不通。”
 
因此在研究报告中指出,同时检测死细胞和细胞因子是巨噬细胞转变进入修复模式的必要过程。巨噬细胞有一个探测器触发他们的组织修复项目。在修复感染和炎症的过程中,巨噬细胞主要有两方面的作用,其一是巨噬细胞分泌的多种活性物质直接引导机体进行修复;其二则是作为身体的清道夫,清理受损组织中的坏死病原体,理解这种分子修复机制可以带来更好的应对炎症的方法,对于炎症引起的慢性疾病,如结肠炎等。

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    2017-05-29 189****7206

    学习了谢谢分享。

    0

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    2017-05-26 184****9840

    学习了谢谢分享。

    0

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    2017-05-19 130****4638

    炎症反应领域的进步。

    0

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    2017-05-18 189****7206

    学习了,不错。

    0

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    2017-05-17 189****7206

    如果能找到机理确实是进步了。

    0

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    2017-05-17 jichang
  7. [GetPortalCommentsPageByObjectIdResponse(id=203744, encodeId=bbbf203e44a7, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Mon May 29 00:18:08 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202864, encodeId=74882028642e, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Fri May 26 17:42:40 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200091, encodeId=50612000911e, content=炎症反应领域的进步。, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Fri May 19 20:13:45 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199725, encodeId=5591199e2547, content=学习了,不错。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Thu May 18 23:17:00 CST 2017, time=2017-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199326, encodeId=780319932660, content=如果能找到机理确实是进步了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Wed May 17 21:20:28 CST 2017, time=2017-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375584, encodeId=5c6b13e558478, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Wed May 17 14:37:00 CST 2017, time=2017-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=198732, encodeId=59fb198e32ce, content=炎症反应的新发现,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Tue May 16 10:21:51 CST 2017, time=2017-05-16, status=1, ipAttribution=)]
    2017-05-16 130****4638

    炎症反应的新发现,学习了。

    0

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