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Eur Respir J:静脉注射甲基强的松龙治疗重症COVID-19患者的疗效

2020-09-18 MedSci原创 MedSci原创

该研究的结果表明,甲基强的松龙治疗可能是住院的重症COVID-19肺部患者有效治疗方法。

目前尚无明确有效的2019年严重冠状病毒病(COVID-19)治疗药物;因此,建议将甲基泼尼松龙作为免疫抑制剂,以减轻呼吸系统的炎症。

近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员进行了一项单盲、随机、对照、临床试验,研究对象为伊朗疾病早期确诊为COVID-19的重症住院患者。患者采用区组随机分配方法按1:1的比例分别接受甲基强的松龙(静脉注射,250mg/天,3 d天)加标准治疗或仅接受标准治疗。研究终点是临床改善或死亡的时间,以先到者为准。研究人员在意向性治疗(ITT)人群中进行了主要和安全性分析。

自2020年4月20日至2020年6月20日,研究人员对68例符合条件的患者进行了随机分组(每组34例)。在标准治疗组中,有6例患者在治疗期间由主治医师判断后给予了皮质类固醇治疗,并从ITT人群中排除。甲基强的松龙组临床改善的患者高于标准治疗组(94.1% vs. 57.1%),甲基强的松龙组的死亡率在数值上更低(5.9% vs. 42.9%;p< 0.001)。该研究证实了甲基强的松龙干预组患者的生存时间比标准治疗组的患者显著延长[对数秩检验:p<0.001;风险比:0.293; 95%C I:0.154–0.556]。每组中共有两名患者(分别为5.8%和7.1%)在治疗开始至研究结束之间出现严重不良事件。

由此可见,该研究的结果表明,甲基强的松龙治疗可能是住院的重症COVID-19肺部患者有效治疗方法。

原始出处:

Maryam Edalatifard,et al.Intravenous methylprednisolone pulse as a treatment for hospitalised severe COVID-19 patients: results from a randomised controlled clinical trial.Eur Respir J.2020.https://erj.ersjournals.com/content/early/2020/09/09/13993003.02808-2020

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    2021-05-08 fusion
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    2020-09-19 12412355m93暂无昵称

    好的,糖皮质激素的使用,我是认为有效的,短期使用,曾经救过我的命。1970年代,刚有,中毒性菌痢,休克时用的。

    0

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    2020-09-18 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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