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GUT：他汀类药物与结肠镜后结肠直肠癌

2019-03-05 zhangfan MedSci原创

结肠镜后结肠直肠癌CRC他汀类药物
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研究认为，他汀类药物可降低结肠镜后结肠直肠癌风险，特别是近端癌

结肠镜后结肠直肠癌(PCCRC)占全部大肠癌的9%以上，现已证实他汀类药物可降低CRC风险，近日研究人员就他汀类药物对PCCRC的影响进行了考察。

本次研究在香港开展，40岁以上接受直肠镜检测人群参与研究，接受至少90天他汀类药物治疗，随访5年，PCCRC-3Y定义为在结肠镜检查后6-36个月内诊断的癌症。

187897患者参与研究，其中854人(0.45%)诊断为PCCRC-3y，他汀类药物可降低PCRCRC-3Y风险相关（SHR：0.72）。亚组分析显示，他汀类药物对近端和远端CRC的预防效果存在差异（SHR：0.5；SHR：0.8）。60岁以上老年、女性、非糖尿病以及息肉人群更受益于他汀类药物。

研究认为，他汀类药物可降低结肠镜后结肠直肠癌风险，特别是近端癌。

原始出处：


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    2019-05-01 ms6390871039024434

    #他汀类药#

    0

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    2019-03-07 zhouqu_8

    #肠镜#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2044544, encodeId=f5122044544ec, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Wed May 01 14:09:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434473, encodeId=4c4614344e3b1, content=<a href='/topic/show?id=95de81e4889' target=_blank style='color:#2F92EE;'>#肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81748, encryptionId=95de81e4889, topicName=肠镜)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Mar 07 06:09:00 CST 2019, time=2019-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586941, encodeId=2e381586941d7, content=<a href='/topic/show?id=a8fae87846b' target=_blank style='color:#2F92EE;'>#结肠直肠癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78784, encryptionId=a8fae87846b, topicName=结肠直肠癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=87c517396713, createdName=lmm403, createdTime=Thu Mar 07 06:09:00 CST 2019, time=2019-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362053, encodeId=8b83362053ef, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Tue Mar 05 20:44:03 CST 2019, time=2019-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362042, encodeId=6afb362042ec, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Tue Mar 05 17:34:16 CST 2019, time=2019-03-05, status=1, ipAttribution=)]
    2019-03-07 lmm403

    #结肠直肠癌#

    0

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    2019-03-05 医者仁心5538

    学习了

    0

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    2019-03-05 329523732

    不错

    0

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