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Eur Heart J:稳定型冠心病患者随访血压变异性和心血管预后相关性分析!

2017-05-28 xing.T MedSci原创

由此可见,在稳定型冠心病患者中,较高的收缩压和舒张压变异是心血管事件的风险增加的强预测因子,并且独立于平均血压。

近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员旨在探讨稳定型冠心病患者随访血压变异与心血管风险之间的相关性。

研究人员分析了来自于稳定型冠心病患者采用darapladi或安慰剂治疗试验(STABILITY试验)的15828例患者的数据,血压变异性的评估指标包括随机化后前1年内5次(基础、1、3、6、12月)血压测量的收缩压标准差(SD)、舒张压SD、最高血压和最低血压。

研究人员发现第一年参与者平均血压的数值(SD)为131(13.7) 毫米汞柱在78.3(8.3) 毫米汞柱。收缩压随访期间SD的平均值(SD)为9.8(4.8) 毫米汞柱,舒张压为6.3(3) 毫米汞柱。

在随后的2.6 年随访期间,1010例患者达到了该研究的主要终点,即发生心血管死亡、心肌梗死卒中的复合时间。在调整了研究第一年期间平均血压、基线血管疾病、治疗、肾功能和心血管疾病危险因素的Cox回归模型中,该研究的主要终点与收缩压的SD(最高三分位数与最低三分位数相比风险比为1.30,95%可信区间为1.10-1.53,P=0.007)以及舒张压的SD(最高三分位数与最低三分位数相比风险比为1.38,95%可信区间为1.18-1.62,P<0.001)相关。血压峰值和波谷也与不良事件独立相关。

由此可见,在稳定型冠心病患者中,较高的收缩压和舒张压变异是心血管事件的风险增加的强预测因子,并且独立于平均血压。

原始出处:

Emmanuelle Vidal-Petiot,et al. Visit-to-visit variability of blood pressure and cardiovascular outcomes in patients with stable coronary heart disease. Insights from the STABILITY trial. Eur Heart J. https://doi.org/10.1093/eurheartj/ehx250

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content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue May 30 06:07:00 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204196, encodeId=1f1020419659, content=血压因素很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Tue May 30 05:23:13 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204099, encodeId=ea072040992c, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon May 29 21:29:04 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-30 zhaojie88
  5. 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content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue May 30 06:07:00 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204196, encodeId=1f1020419659, content=血压因素很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Tue May 30 05:23:13 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204099, encodeId=ea072040992c, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon May 29 21:29:04 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
  6. 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content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue May 30 06:07:00 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204196, encodeId=1f1020419659, content=血压因素很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Tue May 30 05:23:13 CST 2017, 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  7. 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  8. 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time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204099, encodeId=ea072040992c, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon May 29 21:29:04 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-30 slcumt
  9. 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time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204099, encodeId=ea072040992c, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon May 29 21:29:04 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-30 lou.minghong

    血压因素很重要

    0

  10. 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content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue May 30 06:07:00 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204196, encodeId=1f1020419659, content=血压因素很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Tue May 30 05:23:13 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204099, encodeId=ea072040992c, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon May 29 21:29:04 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-29 虈亣靌

    学习了谢谢分享

    0

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近红外光谱(Near-infrared spectroscopy,NIRS)能量化冠状动脉内的胆固醇的脂质核心负荷指数(LCBI)。研究人员研究了在冠状动脉疾病(CAD)患者中长期随访心脏不良结局时,由近红外光谱导出的LCBI的预后情况。研究共纳入了2009-2013年间,在275例经冠状动脉造影确诊的急性冠脉综合征(ACS)和稳定型心绞痛患者的非梗死动脉的近红外光谱数据。通过独立的corelab

OCC 2017:韩雅玲院士——冠心病介入治疗新近进展

今天召开第11届东方心脏病学会议(OCC)上,来自沈阳军区总医院全军心血管病研究所心内科的韩雅玲院士从三个方面:心肌血运重建策略的新证据、PCI相关的药物治疗进展、新型支架研究进展,回顾了2016~2017年以来冠心病介入治疗领域的新进展。 一、 心肌血运重建策略的新证据 1.EXCEL研究选取了2905名上低中危(SYNTAX得分≤32)无保护左主干患者,最终纳入1905名患者比

JAHA:1型纤溶酶原激活物抑制物对冠心病的因果效应!

该研究的结果表明,升高的PAI-1水平对CHD风险存在因果效应,可能是通过葡萄糖代谢功能障碍所介导。

Circulation:迄今为止大规模的冠心病「基因-吸烟」研究显示,吸烟简直就是作死

宾夕法尼亚大学的研究人员开展了一项涉及14.1万人的研究,终于找到了基因学证据来解释吸烟是如何导致冠心病的。吸烟会增加一种酶的产生,而这种酶会促进冠状动脉脂肪斑块的积聚,从而增加冠心病的患病风险[1]!

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