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Int J Oncol：Let-7或可通过化疗增敏有效治疗食管癌

2017-10-21 MedSci MedSci原创

Let-7化疗食管癌
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食管癌的治疗效果差，预后差，使得其成为最可怕的恶性癌之一，即便是多学科联合治疗仍无法实现患者的长期无病生存。本研究旨在早期诊断食管癌，改善抗癌治疗效果，从而提高治疗效果。采用回顾性分析，对接受食管切除术的患者癌症样本进行分析，结果发现，ALDH1或CD133阳性的癌症干细胞的比例与2年复发相关。较高比例的癌症干细胞表明较差的临床分期，Wnt信号激活更为频繁。进一步在实验研究中，研究人员探讨了在EC

食管癌的治疗效果差，预后差，使得其成为最可怕的恶性癌之一，即便是多学科联合治疗仍无法实现患者的长期无病生存。本研究旨在早期诊断食管癌，改善抗癌治疗效果，从而提高治疗效果。

采用回顾性分析，对接受食管切除术的患者癌症样本进行分析，结果发现，ALDH1或CD133阳性的癌症干细胞的比例与2年复发相关。较高比例的癌症干细胞表明较差的临床分期，Wnt信号激活更为频繁。进一步在实验研究中，研究人员探讨了在ECA-109和ECA-9706食管癌干细胞中Let-7自我更新的抑制作用和机制。

分离的癌症干细胞可自然地对称分裂，且具有抗药性。氟尿嘧啶和多西紫杉醇的治疗都促进了干细胞的增殖，证明了干细胞的耐药性。Wnt激活刺激干细胞的更对称分裂，导致自我更新促进，这可能被Let-7过表达而阻断。此外，增强Let-7使干细胞以Wnt通路抑制依赖的方式致敏化疗，有助于Let-7的化疗增敏作用。Wnt激活后通过CCAT-1的海绵功能削弱了对Let-7b的抑制，形成了Let-7b/Wnt/CCAT1的负反馈回路。

总之，这些结果确定了干细胞在食管癌发生和进展中作为有效指标参与，且Let-7纳米颗粒在癌症治疗中潜在的强大作用。

原始出处：

Yamei Pang, Jian Liu, et al., Nano Let-7b sensitization of eliminating esophageal cancer stem-like cells is dependent on blockade of Wnt activation of symmetric division. Int J Oncol. 2017 Oct; 51(4): 1077–1088. Published online 2017 Aug 29. doi: 10.3892/ijo.2017.4104

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    2017-10-30 minlingfeng

    #Oncol#

    0

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    2017-10-23 zhouqu_8

    #食管#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1865156, encodeId=d6e018651567d, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Oct 30 10:17:00 CST 2017, time=2017-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437265, encodeId=e92f143e2656a, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Oct 23 12:17:00 CST 2017, time=2017-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619492, encodeId=9d6816194922c, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon Oct 23 12:17:00 CST 2017, time=2017-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254937, encodeId=683e25493e43, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Oct 21 22:32:30 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-10-23 docwu2019

    #有效治疗#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1865156, encodeId=d6e018651567d, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Oct 30 10:17:00 CST 2017, time=2017-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437265, encodeId=e92f143e2656a, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Oct 23 12:17:00 CST 2017, time=2017-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619492, encodeId=9d6816194922c, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon Oct 23 12:17:00 CST 2017, time=2017-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254937, encodeId=683e25493e43, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Oct 21 22:32:30 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-10-21 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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