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Molecular Cell:全新发现,这款药物不仅可治疗卵巢癌、前列腺癌及胰腺癌还可治疗脑部疾病!

2018-08-11 佚名 转化医学网

肌萎缩侧索硬化ALS是运动神经元疾病,病程晚期进展为全身肌肉萎缩和吞咽困难,最后产生呼吸衰竭,TDP-43是一个重要的致病相关蛋白,宾夕法尼亚研究小组发现PARP抑制剂可以阻止 PAR的产生,从而减少TDP-43的有害影响,此项研究发表在《Molecular Cell》上。


导  读

肌萎缩侧索硬化ALS是运动神经元疾病,病程晚期进展为全身肌肉萎缩和吞咽困难,最后产生呼吸衰竭,TDP-43是一个重要的致病相关蛋白,宾夕法尼亚研究小组发现PARP抑制剂可以阻止 PAR的产生,从而减少TDP-43的有害影响,此项研究发表在《Molecular Cell》上。

PARP抑制剂是一种能够影响癌细胞的自我复制方式的医学用剂。PARP通过抑制肿瘤细胞DNA损伤修复、促进肿瘤细胞发生凋亡,可以增强乳腺癌药物有效发挥作用,还可以治疗卵巢癌、前列腺癌、乳腺癌等拥有相同基因的遗传性癌症。

宾夕法尼亚大学的团队通过在培养细胞上测试PARP抑制剂观察到了TDP-43积累量的下降,实验结果显示,PARP抑制剂可用于治疗脑部疾病额颞叶变性FTLD和肌萎缩侧索硬化ALS。

肌萎缩侧索硬化ALS主要的病理表现为异常蛋白的积聚和神经炎症,TDP-43是一个重要的致病相关蛋白,当它位于细胞核外时会形成团块。蛋白质与一种叫做聚(ADP-核糖)聚合酶(PAR)的分子结合,宾夕法尼亚研究小组发现PARP抑制剂可以阻止 PAR的产生,从而减少TDP-43的有害影响。

Leeanne McGurk博士表示:“令我兴奋的是追踪这条途径是小分子攻击TDP-43疾病过程的前景。”

宾夕法尼亚大学的研究人员认为PARP抑制剂可以用于脑部疾病。该大学生物学教授团队联合负责人Nancy Bonini博士说:“鉴于缺乏治疗方案,我们对这些实验感到兴奋,这些实验有助于阐明PARP抑制剂应用于脑部疾病的原理。”

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    2019-01-24 维他命
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    2018-08-12 kafei

    学习学习谢谢

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1870805, encodeId=55b418e080598, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Jun 29 11:01:00 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921230, encodeId=8f551921230ce, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Tue Aug 21 12:01:00 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961075, encodeId=fc9419610e502, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Jan 24 11:01:00 CST 2019, time=2019-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037407, encodeId=e56a203e4075d, content=<a href='/topic/show?id=1af68515859' target=_blank style='color:#2F92EE;'>#脑部疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85158, encryptionId=1af68515859, topicName=脑部疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Sun Jun 16 11:01:00 CST 2019, time=2019-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=338017, encodeId=522933801e58, content=学习学习谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sun Aug 12 00:35:03 CST 2018, time=2018-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=337998, encodeId=498033e998ec, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Aug 11 23:39:48 CST 2018, time=2018-08-11, status=1, ipAttribution=)]
    2018-08-11 惠映实验室

    学习了,谢谢分享。

    0

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