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AJCN:中心性肥胖测量与HIV患者心血管疾病风险的预测指标高度一致

2018-06-17 MedSci MedSci原创

研究人员发现接受高活性抗逆转录病毒疗法(HAART)的HIV患者体内体脂会重新分布,其代谢异常常会促成动脉粥样硬化,增加心血管疾病风险。本项研究旨在评估找出与HIV患者动脉粥样硬化相关的指标。

背景:研究人员发现接受高活性抗逆转录病毒疗法(HAART)的HIV患者体内体脂会重新分布,其代谢异常常会促成动脉粥样硬化,增加心血管疾病风险。本项研究旨在评估找出与HIV患者动脉粥样硬化相关的指标。

方法:为了评估HIV患者心血管疾病风险,研究人员进行了心电图检查,测量了踝臂指数和血压动脉高压,进行了脂质生化测试,并测量了血糖,并测量了腰围(WC),臀部,大腿,小腿,颈部,躯干和皮褶厚度(肱二头肌,肱三头肌,肩胛下,上髂骨),进行生物电阻抗分析(BIA)和相关指标[体重指数,腰臀比,腰围与小腿比,腰围与身高比(WHtR),躯干与手臂比例,体脂质量校正的体重指数,身体肥胖指数,锥度指数,体形指数,脂肪质量(百分比)和相位角]。

结果: 中心肥胖WC和WHtR测量显示最佳表现 :男性WC(AUC)为0.83(95%CI:0.78,0.89; P  <0.05); 女性的WC AUC:0.86(95%CI:0.81,0.91; P  <0.05); 男性WHTR AUC:0.83(95%CI:0.78,0.88; P  <0.05); 和女性WHtR AUC:0.85(95%CI:0.80,0.91; P  <0.05)。所有肥胖指标均与艾滋病毒血清阴性人群提出的截距不同。WC的临界值为男性为87.75 cm(敏感度为82.2%,特异度为75.5%),女性为90.5 cm(敏感度为84.0%;特异度为73.0%)。

结论:中心性肥胖的测量指标与心血管疾病风险的预测因子呈显着的相关性,并且本研究中提出的临界点的使用旨在有助于及早发现心血管疾病风险的增加,从而实现早期干预。

原始出处:
Rebeca A Beraldo.et al.Anthropometric measures of central adiposity are highly concordant with predictors of cardiovascular disease risk in HIV patients. The American Journal of Clinical Nutrition.2018.

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    2018-09-25 苏小雨

    学习了学习了

    0

  3. 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    2018-06-19 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

  4. 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likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun Jun 17 19:19:08 CST 2018, time=2018-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324987, encodeId=232332498e98, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jun 17 19:12:09 CST 2018, time=2018-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324961, encodeId=c527324961b6, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jun 17 15:34:59 CST 2018, time=2018-06-17, status=1, ipAttribution=)]
    2018-06-17 changjiu

    学习一下谢谢

    0

  8. 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likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun Jun 17 19:19:08 CST 2018, time=2018-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324987, encodeId=232332498e98, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jun 17 19:12:09 CST 2018, time=2018-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324961, encodeId=c527324961b6, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jun 17 15:34:59 CST 2018, time=2018-06-17, status=1, ipAttribution=)]
    2018-06-17 中医痴

    不错的.学习了.谢谢分享.

    0

  9. 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encodeId=c527324961b6, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jun 17 15:34:59 CST 2018, time=2018-06-17, status=1, ipAttribution=)]
    2018-06-17 清风拂面

    谢谢分享学习

    0

  10. 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    2018-06-17 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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Cell Reports:HIV如何经由性途径感染新宿主

尽管大家都知道HIV通过性传播,但是,科学界至今仍不清楚病毒如何经由生殖细胞粘液膜到达它们的免疫系统靶标。先前有研究在生化水平调查过HIV传播过程中各个时间点的测量值,直到今天,法国领导的一项研究终于直观地看到了这个“惊心动魄”的过程。文章发表于5月8日的《Cell Reports》。

Int J Tuberc Lung Dis:在HIV共感染的MDR-TB患者中,氨基糖苷类诱导的听力损失风险增加

多重抗药性结核病(MDR-TB)患者中很高比例由于注射氨基糖苷类(AGs)引起的耳毒性从而发展为永久性听力损失。AG诱导的听力损失在结核病(TB)和人类免疫缺陷病毒(HIV)流行的撒哈拉以南非洲国家中的流行程度是最高的。然而,在MDR-TB治疗期间,是否HIV共感染与更高的AG诱导的听力损失相关仍旧存在争议。最近,有研究人员在MDR-TB患者中,评估了HIV共感染对AG诱导的听力损失的影响。研究人

Molecular Therapy Nucleic Acids:复旦团队研制出诱导型基因编辑ZFN靶向切除近10kb 全长HIV-1前病毒

近日,复旦大学生命科学学院遗传工程国家重点实验室朱焕章课题组设计并构建出只在HIV感染细胞上才能切除HIV-1前病毒的诱导型锌指蛋白核酸酶(ZFN-Tat),避免了ZFN持续表达可能引起的潜在脱靶效应,为该技术在临床上安全、有效地应用奠定了基础。相关研究结果近日发表在国际知名期刊《Molecular Therapy- Nucleic Acids》

DCR: 高级别鳞状上皮内病变的检出率可以作为HIV阳性男性确诊的有效依据

高分辨率肛门镜活检是鉴别肛门上皮内瘤变的金标准,但是这一技巧依赖医师的技能,因此差异性很大。而本研究旨在验证高度鳞状上皮内病变检出率是否作可以为HIV阳性男性高分辨率内视镜检查的质量保证指标。

Cell:新发现!揭示 HIV选择休眠的秘密

艾滋病病毒很狡猾,它们会将遗传物质插入感染T细胞的DNA内,形成“病毒库”并以休眠的状态长期存在于患者体内。这些潜伏的病毒是抗艾滋的重中之重。近期,科学家们找到了决定HIV自身保持活跃或者休眠状态的分子机制。这有望带来新的治疗方案,促使病毒“永不苏醒”。

MBio:发现调控HIV潜伏的重要宿主蛋白

5月1日,国际学术期刊mBio在线发表了中国科学院上海巴斯德研究所王建华研究组的研究论文SUN2 modulates HIV-1 infection and latency through association with lamin A/C to maintain the repressive chromatin。该研究揭示了宿主蛋白SUN2与核纤层蛋白lamin A/C相互作用通过维持抑制性染

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