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Neurology:低维生素D、高BMI与儿童发病MS之间因果关系的证据

2017-04-01 xing.T MedSci原创

该研究提供的证据支持降低的维生素D水平和增加的BMI对儿童发病的MS易感性具有独立和因果的效应。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在运用孟德尔随机化通过遗传风险评分(GRS)来估计低血清维生素D浓度、增加的体重指数(BMI)与儿童发病的多发性硬化症(MS)之间的因果关联。

研究人员通过采用每一个风险变异的估计效应计算三个血清25(OH)D水平相关的遗传变异GRS来构建维生素D的工具变量(VitD GRS)。研究人员也构建了一个包含97个与BMI相关的变异累积效应的BMI GRS。参与者包括从美国(n=394例病例,10875例对照者)和瑞典(n=175例病例,5376例对照者,总n=16820)15个地区招募的非西班牙裔白人。

Meta分析结果表明与血清中25(OH)D 水平升高相关的VitD GRS可以降低儿童发病的MS几率(比值比[OR]为0.72,95%可信区间[CI]为0.55-0.94;P=0.02),在控制了性别、遗传血统、HLA-DRB1*15:01和超过100的非人类白细胞抗原MS风险变异后。调整协变量后,BMI GRS和儿童疾病发病之间的相关性也被证实(OR为1.17,95%CI为1.05-1.30;P=0.01)。当在一个多变量模型中进行考虑时,每一个GRS估计都没有发生变化。

该研究提供的证据支持降低的维生素D水平和增加的BMI对儿童发病的MS易感性具有独立和因果的效应。

原始出处:

Milena A. Gianfrancesco, et al. Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS. Neurology. 2017. http://www.neurology.org/content/early/2017/03/29/WNL.0000000000003849.short


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    2017-10-26 yinhl1978
  2. 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    2017-04-05 qjzhai1623

    有治疗效果吗

    0

  3. 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    2017-04-04 Lisa971

    维生素D是临床常用药物。

    0

  4. 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course he is the best and, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKXpC8j9TaoCpG4yIB3skibUZ0ricmVQ6KKIVpqYQxINrmlibsPZSia7GOUupzuINf8UITMib8awsjjkPw/0, createdBy=abbf1713451, createdName=zt123, createdTime=Sun Apr 02 10:49:45 CST 2017, time=2017-04-02, status=1, ipAttribution=)]
    2017-04-04 baihao215

    维生素D和Ms的关系,好好学习一下

    0

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course he is the best and, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKXpC8j9TaoCpG4yIB3skibUZ0ricmVQ6KKIVpqYQxINrmlibsPZSia7GOUupzuINf8UITMib8awsjjkPw/0, createdBy=abbf1713451, createdName=zt123, createdTime=Sun Apr 02 10:49:45 CST 2017, time=2017-04-02, status=1, ipAttribution=)]
    2017-04-03 小鑫啊小心

    近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在运用孟德尔随机化通过遗传风险评分(GRS)来估计低血清维生素D浓度、增加的体重指数(BMI)与儿童发病的多发性硬化症(MS)之间的因果关联。

    0

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    2017-04-03 1e10c84am36(暂无匿称)

    文章不错,值得分享

    0

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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Apr 02 16:48:08 CST 2017, time=2017-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184537, encodeId=4cb518453ea8, content=scvh信了!你说了几, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKXpC8j9TaoCpG4yIB3skibUZ0ricmVQ6KKIVpqYQxINrmlibsPZSia7GOUupzuINf8UITMib8awsjjkPw/0, createdBy=abbf1713451, createdName=zt123, createdTime=Sun Apr 02 10:49:55 CST 2017, time=2017-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184536, encodeId=ab3c184536de, content=上次 vv of course he is the best and, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKXpC8j9TaoCpG4yIB3skibUZ0ricmVQ6KKIVpqYQxINrmlibsPZSia7GOUupzuINf8UITMib8awsjjkPw/0, createdBy=abbf1713451, createdName=zt123, createdTime=Sun Apr 02 10:49:45 CST 2017, time=2017-04-02, status=1, ipAttribution=)]
    2017-04-02 laymankey

    感谢分享一下!

    0

  8. 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    2017-04-02 半夏微凉

    学习了谢谢!

    0

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    2017-04-02 zt123

    scvh信了!你说了几

    0

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    2017-04-02 zt123

    上次 vv of course he is the best and

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