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Plos One:核酸多聚物能在HepaRG细胞和人原代肝细胞中抑制乙肝病毒进入肝细胞

2017-06-25 MedSci MedSci原创

乙肝病毒(HBV)感染仍然是主要的全球性公共卫生问题,目前有2.4亿为HBV慢性感染者,这些患者进展为肝硬化和肝癌的风险非常大。目前现有的药物很少能够真正治愈慢乙肝,因此迫切需要新的抗HBV药物的出现。

乙肝病毒(HBV)感染仍然是主要的全球性公共卫生问题,目前有2.4亿为HBV慢性感染者,这些患者进展为肝硬化和肝癌的风险非常大。目前现有的药物很少能够真正治愈慢乙肝,因此迫切需要新的抗HBV药物的出现。

核酸多聚物(NAPs)是硫代磷酸寡核苷酸,具有强效抑制一些病毒感染的潜力。在慢性感染的人类患者中,NAPs能够降低血清HbsAg和HBV DNA的滴度,促进表面抗原血清学转化为表面抗体,达到"功能性治愈"的目标。此外,NAPs能阻止鸭肝细胞感染鸭乙型肝炎病毒(DHBV),同时在体外和体内都显示出了对DHBV具有抗病毒活性。我们研究了NAPs对HepaRG人肝癌细胞系和原代培养的人肝细胞有特殊的HBV病毒活性。研究评估了在HBV接种时或接种后,带有不同化学特征的NAPs(磷硫化,2'O-甲基核糖核酸,5-甲基胞苷)的抗病毒活性。磷硫化依赖的,非序列依赖的,大小依赖的NAPs具有剂量依赖性地抑制HBV进入。NAPs抑制HBV进入的作用可被2'O-甲基核糖修饰而破坏。在病毒接种后的NAP治疗没有去引起任何抗病毒活性。

原始出处:

Guillot C, Martel N, Berby F, et al. Inhibition of hepatitis B viral entry by nucleic acid polymers in HepaRG cells and primary human hepatocytes. PLoS One. 2017 Jun 21;12(6):e0179697. doi: 10.1371/journal.pone.0179697. eCollection 2017.

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    2017-09-03 xjy02
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    2017-06-29 大爰

    好文章学习了谢谢分享!

    0

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    2017-06-27 gwc384
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