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IBD:治疗干预对梅奥内镜评分为1的溃疡性结肠炎的患者具有延长复发的疗效

2019-03-16 不详 MedSci原创

目前,粘膜愈合(MH)被普遍接受作为溃疡性结肠炎(UC)的治疗终点。最近的研究表明,Mayo内镜评分(MES)为1的患者的临床复发率高于MES为0的患者。因此,本项研究旨在证明二者之间的关系。

背景
目前,粘膜愈合(MH)被普遍接受作为溃疡性结肠炎(UC)的治疗终点。最近的研究表明,Mayo内镜评分(MES)为1的患者的临床复发率高于MES为0的患者。因此,本项研究旨在证明二者之间的关系。

方法
本研究纳入了MES为1且部分Mayo评分≤2的UC患者。研究人员从患者行第一次结肠镜检查(CS)开始随访所有患者。研究人员在治疗干预(第一次CS后立即)组和非治疗干预组之间比较临床复发率,并评估复发的危险因素。

结果
研究人员从2013年至2016年期间接受CS的1523名UC患者中筛选了220名患者纳入本研究。治疗干预患者的临床复发率(P = 0.005)和内镜恶化率(P = 0.11)低于无治疗干预的患者。多变量分析显示,在第一次CS后立即没有治疗干预(临床复发P = 0.001,内镜急性加重P = 0.050)和溃疡性结肠炎内镜下严重血管模式评分(P = 0.021,临床复发,P 内镜下恶化= 0.019)是临床复发和内镜下恶化的危险因素。

结论
对于MES为1的UC患者的治疗干预可以预防疾病复发。

原始出处:

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    2019-04-06 nymo
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    2019-03-18 bnurmamat
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    2019-03-16 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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