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Stroke:S100B血清升高预测脑动静脉畸形破裂患者的院内死亡率

2019-04-09 xing.T 网络

由此可见,血清中升高的S100B蛋白水平与脑动静脉畸形破裂后院内死亡率密切相关。

血清中S100B蛋白水平升高与神经疾病患者的预后不良有关。近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,该研究旨在确定S100B的升高是否与脑动静脉畸形破裂后院内死亡率增加有关。

这是一项针对脑动静脉畸形破裂患者的回顾性研究。研究人群分为派生和验证队列,多因素logistic回归后进行单因素分析用于确定入院后最初48小时内S100B血清水平升高超过0.5μg/L(S100Bmax48)是否与院内死亡率相关。

203例破裂患者符合纳入标准。23例患者住院死亡(11%)。S100Bmax48平均值为0.49±0.62μg/L. 在衍生队列(n=101破裂)中,多变量分析发现格拉斯哥昏迷量表评分≤8(比值比为21; 95%CI为2-216; 0.001)和S100Bmax48>0.5μg/L(比值比为19; 95%CI为2-188; P=0.001)与院内死亡率相关。当应用于验证队列(n=102破裂)时,相同模型仅发现S100Bmax48>0.5μg/L(比值比为8; 95%CI为1.5-44; P=0.01)与院内死亡率相关。

由此可见,血清中升高的S100B蛋白水平与脑动静脉畸形破裂后院内死亡率密切相关。

原始出处:

Eimad Shotar.et al.S100B Serum Elevation Predicts In-Hospital Mortality After Brain Arteriovenous Malformation Rupture.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.025033

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    2019-09-09 fusion
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    2019-12-21 tamgche
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    2019-04-18 jin321

    这也可以?

    0

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    2019-04-09 龙胆草

    学习谢谢分享

    0

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