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Diabetic Med:日本妊娠期糖尿病患者产后早期葡萄糖耐受不良的预测因素

2018-11-01 MedSci MedSci原创

近日,国际杂志 《Diabetic Med》上在线发表一项关于日本妊娠期糖尿病患者产后早期葡萄糖耐受不良的预测因素决策曲线分析的研究。通过决策曲线分析,确定妊娠期糖尿病患者早产后葡萄糖耐受不良的预测因素。 本研究中进行了一项回顾性队列研究。参与者是123名患有妊娠糖尿病的日本女性,她们在分娩后8-12周接受了75g口服葡萄糖耐量试验。根据产后口服葡萄糖耐量试验结果将它们分为葡萄糖耐受不良组

近日,国际杂志 《Diabetic Med》上在线发表一项关于日本妊娠期糖尿病患者产后早期葡萄糖耐受不良的预测因素决策曲线分析的研究。通过决策曲线分析,确定妊娠期糖尿病患者早产后葡萄糖耐受不良的预测因素。

本研究中进行了一项回顾性队列研究。参与者是123名患有妊娠糖尿病的日本女性,她们在分娩后8-12周接受了75g口服葡萄糖耐量试验。根据产后口服葡萄糖耐量试验结果将它们分为葡萄糖耐受不良组和正常葡萄糖耐受组。分析妊娠口服葡萄糖耐量试验结果显示产后葡萄糖耐受不良的预测因素。研究人员还基于决策曲线分析评估了预测模型的临床有效性。

研究结果显示,在123名女性中,78名(63.4%)患有血糖异常,45名(36.6%)患有葡萄糖耐受不良。多变量逻辑回归分析显示,在妊娠期口服葡萄糖耐量试验(总葡萄糖)期间评估的胰岛素原指数/空腹免疫反应性胰岛素和葡萄糖水平的总和是产后葡萄糖耐受不良的独立危险因素。评估回归模型,使用基本模型(即年龄,糖尿病家族史,BMI25kg/ m 2)怀孕期间使用胰岛素和胰岛素原指数/空腹免疫反应性胰岛素<1.1获得了最佳辨别力(曲线下面积0.725)。决策曲线分析表明,将胰岛素指数/空腹免疫反应性胰岛素<1.1与基础临床信息相结合,可以为预测产后葡萄糖耐受不良提供更好的净效益。

研究表明,在妊娠期间使用口服葡萄糖耐量试验结果计算的胰岛素原指数/空腹免疫反应性胰岛素可能对预测妊娠期糖尿病患者的早期产后葡萄糖耐受不良有一定作用。

原始出处:

M. Kondo Y. Nagao M. H. Mahbubet al. Factors predicting early postpartum glucose intolerance in Japanese women with gestational diabetes mellitus: decisioncurve analysis

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042000, encodeId=ae691042000f3, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Nov 01 17:37:00 CST 2018, time=2018-11-01, status=1, ipAttribution=)]
  5. 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time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042000, encodeId=ae691042000f3, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Nov 01 17:37:00 CST 2018, time=2018-11-01, status=1, ipAttribution=)]
  6. 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  7. 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  8. 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  9. 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    2018-11-01 misszhang

    谢谢MedSci提供最新的资讯

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