Clinica Chimica Acta：多中心研究评价高灵敏度cTnI方法第99百分位数及参考值的变化

2019-08-08 gladiator MedSci原创

意大利临床生物化学学会<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:"Calibri","sans-serif"; mso-fareast-font-family:宋体;mso-bidi-font-family:"Times New

意大利临床生物化学学会(SIBioC)和欧洲配体分析学会(ELAS)意大利分会最近推进了一项多中心研究(意大利hs-cTnI研究)，目的是评估意大利市场上最流行的cTnI方法的分析性能和参考价值。本文的目的是报告意大利hs-cTnI关于访问cTnI方法的第99个百分位URL和第99个URL参考变化（RCV）值评估的研究结果。

研究结果显示，8个意大利临床中心共收集了1306名健康成人志愿者的肝素血浆样本。其中，每个中心收集了50到150个健康成人的血浆样本。所有志愿者均否认存在慢性或急性疾病，且常规实验室检测值(包括肌酐、电解质、葡萄糖和血细胞计数)均正常。457名成年受试者（平均年龄63.0岁; SD 8.1岁，最小47岁，最大86岁）的老年队列也进行了ECG和心脏成像分析，以排除无症状心脏病的存在。

本研究结果证实，使用DxI平台的Access hsTnI方法符合国际cTn检测高灵敏度方法指南要求的两个标准。此外，本研究的结果证实，第99百分位URL值的计算不仅受参考群体年龄和性别的影响较大，而且受计算cTnI分布参数的统计方法的影响也较大。

原始出处：

Aldo Clerico，Andrea Ripoli，Evaluation of 99th percentile and reference change values of a high-sensitivity cTnI method: A multicenter study

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评论区 (6)

#插入话题

插入图片

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2019-11-15 shanyongle

#cTnI#

52 0
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2020-03-30 windight

#CTA#

42 0
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2020-03-05 respect

#灵敏度#

64 0
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2020-03-19 luoxiaog

#多中心#

51 0
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2019-12-18 redcrab

#多中心研究#

47 0
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2019-08-10 huagfeg

#评价#

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