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JACC:在缺血性和非缺血性心衰患者中,T2DM都可以预测死亡

2016-09-22 MedSci MedSci原创

心衰(HF)是2型糖尿病(T2DM)患者常见和严重的并发症。然而,此类患者的缺血性HF和血管重建的预后还没有很好地被调查。该研究的目的是在一个有和没有T2DM的患者群中,调查缺血性与非缺血HF和以前血运重建对该患者群的长期预后影响。在瑞典心衰注册(SwedeHF)中,研究人员通过糖尿病状态和缺血性或非缺血性HF,以及血运重建史对患者进行分层,研究人员在2003年至2011年期间对这些患者进行了随访

心衰(HF)是2型糖尿病(T2DM)患者常见和严重的并发症。然而,此类患者的缺血性HF和血管重建的预后还没有很好地被调查。

该研究的目的是在一个有和没有T2DM的患者群中,调查缺血性与非缺血HF和以前血运重建对该患者群的长期预后影响。

在瑞典心衰注册(SwedeHF)中,研究人员通过糖尿病状态和缺血性或非缺血性HF,以及血运重建史对患者进行分层,研究人员在2003年至2011年期间对这些患者进行了随访,探讨了这些患者的死亡预测因子和寿命。倾向评分分析用来评估之前血运重建的影响。

在35163例心衰患者中,患有2型糖尿病的患者都较年轻,并且90%的患者有1个或多个相关合并症。T2DM患者的缺血性心脏疾病(IHD)发病率为62%,而无2型糖尿病患者的IHD发病率为47%,在这些患者中,分别有53%和48%的患者经历了血运重建。不管IHD是否存在,T2DM都可以预测死亡,那些有和无IHD患者调整后的危险比(HR)和95%可信区间(CI)分别为1.40(1.33至1.46)和1.30(1.22至1.39)。兼有T2DM和IHD的患者有最高的死亡率,如果没有血运重建,该死亡率会更高(调整后的HR:0.82; 95%CI:0.75至0.91)。倾向评分的调整并没有改变这些结果(HR:0.87; 95%CI:0.78至0.96)。血运重建并没有消除T2DM的影响,在那些有血运重建史(HR:1.36; 95%CI:1.24至1.48)和无血运重建史(HR:1.45; 95%CI:1.33至1.56)的患者中,T2DM都可以预测死亡。

90%的T2DM心衰患者都有可以预防的合并症。在T2DM患者中,IHD对死亡有负面影响,然而这些患者可以受益于之前的血运重建史。

原始出处:

Isabelle Johansson,Ulf Dahlström,Magnus Edner,et al.Prognostic Implications of Type 2 Diabetes Mellitus in Ischemic and Nonischemic Heart Failure,JACC,2016.9.21


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    2017-02-26 hbwxf
  3. 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  4. [GetPortalCommentsPageByObjectIdResponse(id=1892794, encodeId=cddc1892e9443, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Mon Jul 24 14:08:00 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853575, encodeId=226918535e5f7, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Feb 26 02:08:00 CST 2017, time=2017-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037280, encodeId=4762203e280eb, content=<a href='/topic/show?id=8333e9371db' target=_blank style='color:#2F92EE;'>#缺血性心衰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79371, encryptionId=8333e9371db, topicName=缺血性心衰)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Jr8S1dfvNyP22t32IFDXJXnpd5AGlDibiajL5cl3pxj7OPCeAeibLhzOmZn5Q2Oicc6uKOCnxGNOggdLtI3hIW7huQ/132, createdBy=66e52500008, createdName=Tamikia, createdTime=Fri Nov 18 23:08:00 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138219, encodeId=5cc61382192e, content=理论需要实践检验。, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Sep 30 17:31:06 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135523, encodeId=9830135523c0, content=缺血和非缺血性心衰患者需要科学治疗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Mon Sep 26 19:53:17 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=134995, encodeId=058d134995ca, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Sep 25 12:14:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=134996, encodeId=a54513499688, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Sep 25 12:14:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325295, encodeId=0105132529578, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Sep 24 05:08:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373320, encodeId=986b13e3320d2, content=<a href='/topic/show?id=2fd051939ab' target=_blank style='color:#2F92EE;'>#心衰患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51939, encryptionId=2fd051939ab, topicName=心衰患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sat Sep 24 05:08:00 CST 2016, time=2016-09-24, status=1, ipAttribution=)]
    2016-09-30 jyzxjiangqin

    理论需要实践检验。

    0

  5. 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    2016-09-26 jyzxjiangqin

    缺血和非缺血性心衰患者需要科学治疗。

    0

  6. 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    2016-09-25 doctorJiangchao

    继续学习

    0

  7. 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    2016-09-25 doctorJiangchao

    继续关注

    0

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