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Nat Commun:新研究揭示lncRNA FILNC1在癌症代谢中的作用机制

2017-10-11 MedSci MedSci原创

目前关于长期非编码RNA在癌症代谢中的作用仍知之甚少。本研究中,研究人员通过FoxO转录因子鉴定FILNC1(FoxO诱导的长非编码RNA 1)作为能量应激诱导的长非编码RNA。肾癌细胞FILNC1缺乏可减轻能量应激诱导的细胞凋亡,并可明显促进肾肿瘤的发生。本研究结果显示,FILNC1缺乏可通过上调c-Myc增加葡萄糖的摄取和乳酸的产生。在能量应激下,FILNC1与AUF1(一种c-Myc mRN

目前关于长期非编码RNA在癌症代谢中的作用仍知之甚少。本研究中,研究人员通过FoxO转录因子鉴定FILNC1(FoxO诱导的长非编码RNA 1)作为能量应激诱导的长非编码RNA。肾癌细胞FILNC1缺乏可减轻能量应激诱导的细胞凋亡,并可明显促进肾肿瘤的发生。

本研究结果显示,FILNC1缺乏可通过上调c-Myc增加葡萄糖的摄取和乳酸的产生。在能量应激下,FILNC1与AUF1(一种c-Myc mRNA结合蛋白)相互作用,并可阻断AUF1与c-Myc mRNA的结合,导致c-Myc蛋白的表达下调。FILNC1在肾脏中特异性表达,在肾细胞癌中下调;此外,其低表达与肾细胞癌的临床结局较差相关。

总之,该研究结果不仅鉴定了FILNC1是具有潜在临床价值的肾癌阴性调节因子,还揭示了长非编码RNA在控制能量代谢和肿瘤发展中的调节机制。

原始出处:

Zhen-Dong Xiao, Leng Han, et al., Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development. Nat Commun. 2017; 8: 783. Published online 2017 Oct 4. doi: 10.1038/s41467-017-00902-z

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    2018-06-30 liuli5079
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    2017-10-13 xzw113
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    2017-10-11 虈亣靌

    内容丰富.值得学习

    0

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    2017-10-11 有备才能无患

    目前关于长期非编码RNA在癌症代谢中的作用仍知之甚少.

    0

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    2017-10-11 1e0e5a1fm42(暂无匿称)

    henhao

    0

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    2017-10-11 doctorJiangchao

    谢谢分享.

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