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Acta Biomater：两阶段时间依赖型材料可预防植入物相关感染

2019-11-03 不详 网络

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感染是植入失败的主要原因。早期的植入物相关感染通常发生在手术后的前4周。在早期阶段抑制细菌粘附和生物膜形成并促进随后的植入物骨整合对于植入物成功至关重要。我们以前的研究表明，甲基丙烯酸二甲基氨基十二烷基酯（DMADDM）为牙科材料提供了抗菌作用。在本研究中，DMADDM和羟基磷灰石（HA）通过聚多巴胺（PDA）自聚合作用负载在钛（Ti）表面上（Ti-PHD）。在这里，我们报告了Ti-PHD的两阶段

感染是植入失败的主要原因。早期的植入物相关感染通常发生在手术后的前4周。在早期阶段抑制细菌粘附和生物膜形成并促进随后的植入物骨整合对于植入物成功至关重要。我们以前的研究表明，甲基丙烯酸二甲基氨基十二烷基酯（DMADDM）为牙科材料提供了抗菌作用。在本研究中，DMADDM和羟基磷灰石（HA）通过聚多巴胺（PDA）自聚合作用负载在钛（Ti）表面上（Ti-PHD）。

在这里，我们报告了Ti-PHD的两阶段功能：（1）在第一阶段，在植入后4周的高感染风险初期释放DMADDM；（2）然后在第二阶段，增强成骨作用并促进骨整合。Ti-PHD具有比纯Ti更高的平均粗糙度和更大的亲水性的多孔表面。其生物相容性已在体外和体内得到验证。在释放的最初4周内，残留在Ti表面的DMADDM和释放到浸泡介质中的DMADDM都大大降低了病原体的附着和生长。通过预防大鼠骨髓炎模型中的骨破坏进一步证实了这一点。在释放DMADDM 4周后，Ti-PHD可促进人骨髓间充质干细胞（hBMSCs）的成骨分化和体内植入物周围的新骨形成。

综上所述，该研究代表了有关Ti-PHD的两阶段，随时间变化的抗菌和成骨作用的第一份报告，证明了其在临床应用中抑制植入物相关感染的潜力。

原始出处：

Zhou W, Peng X, et al., Two-staged time-dependent materials for the prevention of implant-related infections. Acta Biomater. 2019 Oct 18. pii: S1742-7061(19)30702-0. doi: 10.1016/j.actbio.2019.10.023.

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    2019-12-21 windight

    #CTA#

    0

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    2020-02-14 sunylz

    #Bio#

    0

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    2019-11-05 linagood

    #植入物#

    0

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    2019-11-05 jiyangfei

    #植入#

    0

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