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Clinica Chimica Acta:华北地区不同人群CD36抗原缺乏、血小板同种异体抗体分布及血小板同种异体抗体对妊娠影响?

2019-12-02 gladiator MedSci原创

血小板抗体可导致血小板输血难<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;; mso-fareast-font-family:宋体;mso-bidi-font-family:&quot;Times

血小板抗体可导致血小板输血难(PTR)、胎儿/新生儿同种免疫性血小板减少(FNAIT)临床疾病。本研究旨在了解华北地区不同人群CD36表达、血小板同种抗体分布及血小板同种抗体对妊娠的影响。

已进入以通过采集血液病患者、孕妇、献血者等612例受试者全血标本,检测CD36表达,进行血小板抗体筛选及特异性鉴定。为了调查FNAIT的发生,对1552例产科住院孕妇进行回顾性分析。

研究结果显示,CD36缺乏症表达率为2.12%(13/612),所有病例均为II型缺乏症,而未检出I型缺乏症,总体而言,该率低于华南地区(3.43%)、日本(4.87%)和黑人(4.18%),但高于白人(0.09%)。积极的血小板抗体筛选血液病人组(6.86%,14/204)和孕妇组(6.31%,13/206)高于献血者组(0.49%,1/202),P<. 01。在1552名孕妇中,没有儿童患有FNAIT

研究结果表明,北方地区CD36缺乏的频率较低,均为II型,未检出CD36抗体。推测该人群因CD36缺乏而导致免疫相关血小板减少的风险极低。血液学和多次流产的患者应早期监测血小板抗体。

原始出处:

Chunya MaJinhui WangA single-center investigational study of CD36 antigen deficiency and platelet Chunya Maalloantibody distribution in different populations in Northern China as well as platelet alloantibodies effect on pregnancy

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    2020-09-27 windight
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    2019-12-04 crystal0568
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