Baidu
map

Neurology :类固醇或对治疗食物中毒引发的痉挛昏睡有效

2014-01-20 佚名 生物360

肠出血性大肠杆菌导致食物中毒时,重症患者有时会出现痉挛和昏睡等脑部症状,甚至会死亡。东京大学和富山大学的研究小组发现,如果在短时间内给重症患者大量注射类固醇,可能会取得较好效果。这一成果论文已经刊登在最新一期美国《神经病学》(Neurology)杂志网络版上。 2011 年,日本烤肉连锁店“惠比寿烤肉酒家”的生拌牛肉引发集体食物中毒事件,导致5人死亡,食物中毒是由大肠杆菌 O111 引发的。研

肠出血性大肠杆菌导致食物中毒时,重症患者有时会出现痉挛和昏睡等脑部症状,甚至会死亡。东京大学和富山大学的研究小组发现,如果在短时间内给重症患者大量注射类固醇,可能会取得较好效果。这一成果论文已经刊登在最新一期美国《神经病学》Neurology杂志网络版上。

2011 年,日本烤肉连锁店“惠比寿烤肉酒家”的生拌牛肉引发集体食物中毒事件,导致5人死亡,食物中毒是由大肠杆菌 O111 引发的。研究小组对富山、石川和福井等地的 86 名患者的治疗记录进行了分析。在这些患者中,有 34 人出现了伴随着肾功能衰竭的溶血尿毒综合征,有 21 人出现了痉挛和昏睡等脑部症状。

在最初进行治疗时,医生采用的是血浆交换等治疗手段,但是在开始注射类固醇之后,就不再出现死亡病例,在接受类固醇治疗的 12 名脑部症状患者中,有 11 人没有出现后遗症而康复。研究小组指出,这参考了治疗流感病毒导致的脑部症状时使用类固醇的做法。

在大肠杆菌 O111 导致的食物中毒中,通常有很多患者会出现脑部症状。研究人员表示,对于食物中毒导致的脑部症状,一直缺乏有效的治疗方法,这个发现有可能促进开发出新的治疗方法。

原文出处:

Jun-ichi Takanashi, Hiromichi Taneichi, Takako Misaki, Yuichiro Yahata, Akihisa Okumura, Yoh-ichi Ishida,Toshio Miyawaki, Nobuhiko Okabe, Tetsutaro Sata, and Masashi Mizuguchi. Clinical and radiologic features of encephalopathy during 2011 E coli O111 outbreak in Japan. Neurology, January 17, 2014

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1999367, encodeId=0b76199936e36, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Dec 26 21:47:00 CST 2014, time=2014-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311728, encodeId=10121311e28a5, content=<a href='/topic/show?id=624de11204a' target=_blank style='color:#2F92EE;'>#痉挛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71120, encryptionId=624de11204a, topicName=痉挛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313352, encodeId=57781313352e8, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1318983, encodeId=c8fc131898371, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22315, encryptionId=14d92231508, topicName=中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416647, encodeId=3c3f141664ede, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=)]
    2014-12-26 yinhl1978
  2. [GetPortalCommentsPageByObjectIdResponse(id=1999367, encodeId=0b76199936e36, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Dec 26 21:47:00 CST 2014, time=2014-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311728, encodeId=10121311e28a5, content=<a href='/topic/show?id=624de11204a' target=_blank style='color:#2F92EE;'>#痉挛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71120, encryptionId=624de11204a, topicName=痉挛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313352, encodeId=57781313352e8, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1318983, encodeId=c8fc131898371, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22315, encryptionId=14d92231508, topicName=中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416647, encodeId=3c3f141664ede, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=)]
    2014-01-22 apoenzyme
  3. [GetPortalCommentsPageByObjectIdResponse(id=1999367, encodeId=0b76199936e36, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Dec 26 21:47:00 CST 2014, time=2014-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311728, encodeId=10121311e28a5, content=<a href='/topic/show?id=624de11204a' target=_blank style='color:#2F92EE;'>#痉挛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71120, encryptionId=624de11204a, topicName=痉挛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313352, encodeId=57781313352e8, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1318983, encodeId=c8fc131898371, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22315, encryptionId=14d92231508, topicName=中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416647, encodeId=3c3f141664ede, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1999367, encodeId=0b76199936e36, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Dec 26 21:47:00 CST 2014, time=2014-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311728, encodeId=10121311e28a5, content=<a href='/topic/show?id=624de11204a' target=_blank style='color:#2F92EE;'>#痉挛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71120, encryptionId=624de11204a, topicName=痉挛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313352, encodeId=57781313352e8, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1318983, encodeId=c8fc131898371, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22315, encryptionId=14d92231508, topicName=中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416647, encodeId=3c3f141664ede, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=)]
    2014-01-22 mashirong
  5. [GetPortalCommentsPageByObjectIdResponse(id=1999367, encodeId=0b76199936e36, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Dec 26 21:47:00 CST 2014, time=2014-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311728, encodeId=10121311e28a5, content=<a href='/topic/show?id=624de11204a' target=_blank style='color:#2F92EE;'>#痉挛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71120, encryptionId=624de11204a, topicName=痉挛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313352, encodeId=57781313352e8, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1318983, encodeId=c8fc131898371, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22315, encryptionId=14d92231508, topicName=中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416647, encodeId=3c3f141664ede, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Wed Jan 22 04:47:00 CST 2014, time=2014-01-22, status=1, ipAttribution=)]
    2014-01-22 yhy100201

相关资讯

美国真菌性脑膜炎疫情影响18个州 死者升至25人

  美国疾病控制和预防中心10月26日公布的数据显示,近日在美国一些州肆虐的真菌性脑膜炎疫情已造成至少25人死亡。   美国疾控中心说,目前疫情已影响到18个州,患者超过300人,疫情最严重的仍是田纳西州。各州的染病者都曾注射过马萨诸塞州新英格兰化合中心生产的类固醇。美国食品和药物管理局此前确认,这些类固醇受嘴突脐孢菌污染,是致病源之一。据统计,分布在23个州的约1.4万人注射过受污染类固醇。

卡那奴单抗可治疗青少年特发性关节

     欧美的一项研究表明,卡那奴单抗有效治疗伴发热的活动性青少年全身特发性关节炎(sJIA)。研究证实,卡那奴单抗疗效优于安慰剂,可成功减少类固醇用量,显著降低sJIA复发风险,安全性可接受。   青少年全身特发性关节炎(sJIA) 是由白介素-1β介导的自身炎症性疾病。卡那奴单抗是一种选择性人抗白介素-1β单克隆抗体。本研究通过二个重要的Ⅲ期试验来评价卡那奴单抗的疗

Clin Gastroenterol H:治疗抗TNF所致肝损伤可考虑使用类固醇

       印第安纳大学的Marwan Ghabril博士及其同事在5月刊《临床胃肠病学与肝脏病学》杂志上发表文章指出,继发于抗肿瘤坏死因子α(抗TNFα)药物治疗的肝损伤患者,常常表现出与自发性自身免疫性肝炎相似的组织学改变。         为了确定抗TNF药物性肝损伤的表现、损伤模式、疾病过程和治疗,Gh

美确认91例真菌性脑膜炎病例 7人死亡

  据美国媒体7日报道,美国联邦政府卫生官员称,已确认的真菌性脑膜炎病例上升到91例,其中7人已经死亡,可能还有数以千计的人受到感染。   美国疾病控制与预防中心称,多数的病例发生在南部的田纳西州,当地有32个确诊病例,3人死亡。    引发此次疫情爆发的,是由于一种由马萨诸塞州新英格兰合成药物中心(NECC)生产的类固醇针剂被真菌感染,一些患者在注射被感染针剂后,染上罕见的脑膜炎。

Baidu
map
Baidu
map
Baidu
map