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JCLA:Runx2多态性在后纵韧带骨化症的风险和预后的作用

2017-07-24 MedSci MedSci原创

研究人员从2013年9月至2014年11月期间选择了80名OPLL患者和另外80名无OPLL的患者。采用直接测序分析方法检测Runx2上rs1321075,rs12333172和rs1406846的基因型。

近日,国际杂志 《Journal of Clinical Laboratory Analysis》上在线发表一项关于Runx2多态性在后纵韧带骨化症的风险和预后的作用的研究。旨在调查Runx2 SNP(单核苷酸多态性)是否与后纵韧带(OPLL)骨化的易感性和预后相关。

研究人员从20139月至201411月期间选择了80OPLL患者和另外80名无OPLL的患者。采用直接测序分析方法检测Runx2rs1321075rs12333172rs1406846的基因型。

OPLL与对照组之间的临床特征差异,包括年龄,体重,身高,性别比例以及吸烟史和饮酒史无显著差别(所有P> 0.05)。 rs1406846A)的等位基因是提高OPLL风险的关键因素,具有最大的统计学意义(P <0.001)。相反,rs967588T)和rs16873379C)的等位基因与OPLL的易感性降低相关(P = 0.033)。关于rs16873379,病例组与TT基因型相比,显示出比对照组更小的纯合子CC的频率(P = 0.016)。此外,基于JOA评分计算的改善率表明rs6908650基因型AAOPLL患者后路椎板成形术手术恢复有益( P <0.05),而显著抑制了这一过程(P <.05)。此外,rs16873379rs1406846rs2677108与骨化段​​数显著相关(P <0.05)。

研究表明,Runx2 SNPs(例如rs16873379 rs1406846rs2677108)与OPLL的发作和治疗效果密切相关,并且可能调节OPLL的严重程度。

原始出处:

Feng Chang, Lijun Li, Gang Gao, et.al. Role of Runx2 polymorphisms in risk and prognosis of ossification of posterior longitudinal ligament.

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    2018-03-22 stfoxst
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    2017-07-26 xzw120
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