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Ann Intern Med:肥胖是否与2型糖尿病患者死亡风险有关联?

2015-05-07 徐媛媛译 MedSci原创

这项前瞻性队列研究探讨了在长期随访中,肥胖是否与2型糖尿病患者死亡风险有关联。 研究人员收集了全因死亡率和心血管发病率的信息(如急性冠脉综合征、脑血管意外、和心力衰竭)。调整潜在因素,包括心血管危险因素和病态的条件(如癌症、慢性肾脏疾病和肺部疾病)后,利用Cox回归生存分析,对结果进行分析。 研究人员收纳了10568例2型糖尿病患者,中位随访时间10.6年(随访时间范围:7.8--13.4)。

这项前瞻性队列研究探讨了在长期随访中,肥胖是否与2型糖尿病患者死亡风险有关联。

研究人员收集了全因死亡率和心血管发病率的信息(如急性冠脉综合征、脑血管意外、和心力衰竭)。调整潜在因素,包括心血管危险因素和病态的条件(如癌症、慢性肾脏疾病和肺部疾病)后,利用Cox回归生存分析,对结果进行分析。

研究人员收纳了10568例2型糖尿病患者,中位随访时间10.6年(随访时间范围:7.8--13.4)。患者中位年龄63岁(年龄范围:55-71),其中有54%是男性。与正常体重.的患者相比(BMI,18.5 to 24.9 kg/m2),超重或肥胖(BMI >25 kg/m2)患者的心血管患病率更高(包括急性冠脉综合征、脑血管意外和心衰)。然而,超重(BMI,25--29.9 kg/m2)与低死亡风险相关,而肥胖(BMI >30 kg/m20)患者的死亡风险与正常体重者相似。体重低的患者预后更差。

在这项队列中,超重或肥胖的2型糖尿病患者因心血管疾病住院率更高。超重与死亡风险降低相关,而肥胖与死亡风险降低不相关。

原始出处

Costanzo P, Cleland JG, Pellicori P, Clark AL, Hepburn D, Kilpatrick ES, Perrone-Filardi P, Zhang J, Atkin SL.The obesity paradox in type 2 diabetes mellitus: relationship of body mass index to prognosis: a cohort study.Ann Intern Med. 2015 May 5

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    2015-08-06 hlycom3356

    期待有更多研究

    0

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    2015-05-07 huaxipanxing

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