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Am J Obstet Gynecol:宫颈癌的生存趋势

2015-11-30 candy 译 MedSci原创

目的:近30年宫颈癌的治疗取得了巨大的进展,对于人群水平的生存率是否得到改善,仍然不清楚。研究调查相对生存率,宫颈癌的生存率与不同时间对照比较。设计:研究1983年-2009年间记录在Surveillance、Epidemiology和End Results数据库,被诊断为宫颈癌的病人。生存模型由年龄、种族、分期、每年的诊断和诊断后的时间来调整。比较宫颈癌病人具体分期的相关生存变化和与总人口匹配的

目的:近30年宫颈癌的治疗取得了巨大的进展,但人群水平的生存率是否得到改善,仍然不清楚。研究调查相对生存率,宫颈癌的生存率与不同时间对照比较。

设计:研究1983年-2009年间记录在Surveillance、Epidemiology和End Results数据库,被诊断为宫颈癌的病人。生存模型由年龄、种族、分期、每年的诊断和诊断后的时间来调整。比较宫颈癌病人具体分期的相关生存变化和与总人口匹配的随着时间推移的年龄、种族和年份因素。

结果:共纳入46932例确诊病人。I期宫颈癌女性,2009年被确诊的病人的风险比相较2000年为0.91(95%置信区间0.86-0.95);与1990年比较:HR 0.81(95%CI,0.73-0.91);与1983年比较:HR 0.75(95%CI 0.64-0.88)。III期宫颈癌女性,2009年确诊的病人相对于2000年、1990年和1983年的风险比分别为:0.83 (95% CI, 0.80–0.87),0.68 (95% CI, 0.62–0.75), 0.59 (95% CI, 0.52–0.68)。同样的生存提高趋势表现在II期宫颈癌女性患者中。对于IV期宫颈癌患者则没有表现出随着时间推移相关生存率的提高,其数据无显著统计学意义。

结论:I-III期的宫颈癌患者的相对生存率随着时间提高,但对转移性病人的变化不大。

原始出处:


Wright, J. D., et al. (2015). Population-level trends in relative survival for cervical cancer.Am J Obstet Gynecol 213(5): 670 e671-677.

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    2016-11-06 yhy100200
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    2015-12-02 一闲
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    2015-12-01 cmn

    加油~宫颈癌

    0

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