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Cell stem report：星型胶质细胞分泌过量IL-6或是双向情感障碍治疗新靶点！ 

2021-03-09 MedSci原创 MedSci原创

双相情感障碍细胞因子IL-6星型胶质细胞
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在双相情感障碍患者体内，IL-6至少在一定程度上介导了致炎性星形胶质细胞对神经元活动的影响。

双相情感障碍，也被称为躁郁症，它是一种精神疾病，特征是患者的情绪状态总是在躁狂与抑郁间循环往复。在全世界范围内，大约有1%~3%的人患有双相情感障碍，但截至目前，双相情感障碍的病因还没有被完全知晓。  双相患者患慢性炎症以及炎症相关疾病如心血管疾病、糖尿病和代谢综合征的概率较高。此外，他们具有更高浓度的促炎细胞因子，如IL-1β和IL-6，特别是在躁狂发作期间。  近日，美国索尔克生物研究所的一个研究小组在cell stem report上发表题为Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes的研究论文。  研究结果显示，星形胶质细胞过量分泌的一种叫做白细胞介素-6（IL-6）的促炎分子参与了脑内的炎症级联反应过程，星形胶质细胞分泌因子在调节神经元活动中发挥作用，在双相情感障碍患者体内，IL-6至少在一定程度上介导了致炎性星形胶质细胞对神经元活动的影响。 刺激性炎症使BD星形胶质细胞中IL-6释放增加 研究人员

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    2024-03-16 ms3000002096557062 来自四川省

    学习了

    0

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    2021-08-09 zhaozhouchifen

    #Cell#

    0

  3. 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    2021-08-22 维他命

    #CEL#

    0

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encodeId=9ed114823195b, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Mar 10 16:03:40 CST 2021, time=2021-03-10, status=1, ipAttribution=)]
    2021-12-29 一叶知秋

    #分泌#

    0

  5. 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encodeId=9ed114823195b, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Mar 10 16:03:40 CST 2021, time=2021-03-10, status=1, ipAttribution=)]
    2021-03-15 124219b2m20暂无昵称

    学习了

    0

  6. 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encodeId=9ed114823195b, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Mar 10 16:03:40 CST 2021, time=2021-03-10, status=1, ipAttribution=)]
    2021-03-10 kzlchina

    #IL-6#

    0

  7. 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encodeId=9ed114823195b, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Mar 10 16:03:40 CST 2021, time=2021-03-10, status=1, ipAttribution=)]
    2021-03-10 lsndxfj

    #新靶点#

    0

  8. 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encodeId=9ed114823195b, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Mar 10 16:03:40 CST 2021, time=2021-03-10, status=1, ipAttribution=)]
    2021-03-10 ms1692212821629096

    #胶质细胞#

    0

  9. 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encodeId=9ed114823195b, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Mar 10 16:03:40 CST 2021, time=2021-03-10, status=1, ipAttribution=)]
    2021-03-10 h.y200607_23674418

    #双向情感障碍#

    0

  10. 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encodeId=9ed114823195b, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Wed Mar 10 16:03:40 CST 2021, time=2021-03-10, status=1, ipAttribution=)]
    2021-03-10 12498bb3m92(暂无昵称)

    #STEM#

    0

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与标准治疗组相比，最有效的治疗方法是将皮质类固醇（如地塞米松）与IL-6单抗tocilizumab联合使用。

Nature系列综述：发烧？你真的了解吗？

近日，来自Roswell Park Cancer Institute的免疫学家Daniel t. fisher在nature系列综述性杂志nature reviews immunology发表了一篇综述文章，就发烧与机体免疫应答之间关系的研究进展进行了总结讨论，并对机体诱导发烧产热的信号途径进行了概括，着重强调了细胞因子IL-6以及产热相关的肾上腺素信号途径的重要作用，对未来研究方向进行了推测指导

2024 JSMD实践指南：双相情感障碍

日本心境障碍学会(JSMD,Japanese Society of Mood Disorders) · 2024-08-28

专家共识：早期使用长效注射抗精神病药治疗 I 型双相情感障碍

国外精神科相关专家小组（统称） · 2024-10-22

2023 NICE 临床指南：双相情感障碍的评估和管理 [CG185]

英国国家卫生与临床优化研究所(NICE,National Institute for Health and Clinical Excellence) · 2023-12-21

青春期饮食和双相情绪障碍的合并症：围绕病例报告的诊断考虑

暂未更新 · 2022-12-29

成人ADHD和双相情感障碍:临床和治疗意义

暂未更新 · 2021-05-10

双相情感障碍中医证候辨证分型标准专家共识

中国中西医结合学会精神疾病专业委员会 · 2021-11-30

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