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Tuberc Respir Dis:加巴喷丁治疗慢性咳嗽的疗效和安全性

2018-07-30 MedSci MedSci原创

尽管最近公布了临床指南,但是难治性慢性咳嗽的最佳治疗策略仍然是一个挑战。本系统评价旨在评估加巴喷丁治疗慢性咳嗽的疗效和安全性。检索PubMed,Embase,Cochrane图书馆数据库和出版物。两位评价者根据研究选择的先验标准搜索文章。共确定了7篇相关文章,包括2项随机对照试验,1项连续患者设计的前瞻性病例系列,1例连续患者的回顾性病例系列,1例未知连续状态的回顾性病例系列,2例病例报告,分别包

尽管最近公布了临床指南,但是难治性慢性咳嗽的最佳治疗策略仍然是一个挑战。本系统评价旨在评估加巴喷丁治疗慢性咳嗽的疗效和安全性。

检索PubMed,Embase,Cochrane图书馆数据库和出版物。两位评价者根据研究选择的先验标准搜索文章。

共确定了7篇相关文章,包括2项随机对照试验,1项连续患者设计的前瞻性病例系列,1例连续患者的回顾性病例系列,1例未知连续状态的回顾性病例系列,2例病例报告,分别包括了6例和2例患者。

结果显示,在随机对照试验中使用加巴喷丁治疗后,患者在咳嗽特异性生活质量(莱斯特咳嗽问卷评分)和咳嗽严重程度(视觉模拟评分)方面得到改善。前瞻性病例系列结果显示,使用巴喷丁治疗,咳嗽和感觉神经病变的总体改善率为68%。与安慰剂或标准药物相比,加巴喷丁治疗慢性咳嗽患者的疗效和安全性良好。但是仍需要进一步的随机和对照试验。

原始出处:

Shi G, Shen Q, et al., Efficacy and Safety of Gabapentin in the Treatment of Chronic Cough: A Systematic Review. Tuberc Respir Dis (Seoul). 2018 Jul;81(3):167-174. doi: 10.4046/trd.2017.0089. Epub 2018 Jun 19.

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    2018-07-31 青山颖钰

    学习了

    0

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    2018-07-30 phoebeyan520

    学习了学习了,感谢

    0

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    2018-07-30 yjs木玉

    好好好好好好好好

    0

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    2018-07-30 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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