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J Periodontal Res：药物靶向TRPV4或可用于治疗牙周病

2019-07-27 不详 网络

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作为口腔和牙齿之间的界面，连接上皮屏障对于牙龈防御至关重要。连接上皮受到来自咬合力或外部损伤（例如细菌攻击）的机械应力，但对机械刺激对上皮功能的影响知之甚少。瞬时受体电位香草酸4（TRPV4）作为机械敏感性非选择性阳离子通道起作用。在本研究中，基于TRPV4在小鼠连接上皮中大量表达，我们旨在阐明TRPV4与连接上皮中的连接复合物之间的推定联系。组织学观察显示，TRPV4缺陷型（TRPV4-/-）小

作为口腔和牙齿之间的界面，连接上皮屏障对于牙龈防御至关重要。连接上皮受到来自咬合力或外部损伤（例如细菌攻击）的机械应力，但对机械刺激对上皮功能的影响知之甚少。瞬时受体电位香草酸4（TRPV4）作为机械敏感性非选择性阳离子通道起作用。在本研究中，基于TRPV4在小鼠连接上皮中大量表达，我们旨在阐明TRPV4与连接上皮中的连接复合物之间的推定联系。

组织学观察显示，TRPV4缺陷型（TRPV4-/-）小鼠的交界上皮细胞具有比野生型（TRPV4 +/+）小鼠更宽的细胞间隙。与TRPV4 + / +小鼠相比，TRPV4 TRPV4-/-小鼠中交界上皮中的外源示踪剂穿透更大，并且TRPV4 TRPV4-/-小鼠中粘附连接蛋白的免疫反应性被抑制。对小鼠牙周炎模型的分析显示，与TRPV4 + / +小鼠相比，TRPV4 TRPV4-/-小鼠的骨量减少更多，表明TRPV4 TRPV4-/-小鼠的上皮屏障缺陷可能与牙周并发症有关。

总之，本研究结果确定了TRPV4在结合上皮中粘附连接形成中的关键作用，可调节其渗透性。因此，TRPV4可能是对抗牙周疾病的候选药理学靶标。

原始出处：

Kitsuki T, Yoshimoto RU, et al., Enhanced junctional epithelial permeability in TRPV4-deficient mice. J Periodontal Res. 2019 Jul 25. doi: 10.1111/jre.12685. 

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    2019-10-26 12498bd5m16暂无昵称

    #药物靶向#

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    2019-12-05 feather89

    #PE#

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    2019-07-29 linagood

    #牙周病#

    0

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    2019-07-29 医者仁心

    #牙周#

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