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Circulation:成人先天性心脏疾病患者易发脑卒中

2015-11-25 崔倩 译 MedSci原创

脑卒中是发病和死亡的重要原因,但目前有缺乏关于成人先天性心脏疾病(ACHD)患者其发生率,累积的风险,预测因子的全面数据还比较缺乏。这个回顾性研究包含了29638例魁北克ACHD-患者,他们在1998年至2010年间为18至64岁,该研究是基于对全省范围内的管理数据进行调查的。据估计到64岁时缺血性卒中的累积风险为6.1%(95%-Cl:5.0〜7.0%),男性为7.7%(95%-Cl:6.4-8

脑卒中是发病和死亡的重要原因,但目前关于成人先天性心脏疾病(ACHD)患者的发生率、累积的风险、预测因子的全面数据还比较缺乏。

这个回顾性研究包含了29638例魁北克ACHD-患者,他们在1998年至2010年间为18至64岁,该研究是基于全省范围内的管理数据进行的调查。据估计到64岁时缺血性卒中的累积风险为6.1%(95%-Cl:5.0〜7.0%),男性为7.7%(95%-Cl:6.4-8.8%);出血性卒中的风险分别为0.8%(95%-Cl:0.4-1.2%)和1.3%(95%-Cl:0.8-1.8%)。相比于报道的魁北克一般人群,低于55岁的人群的缺血性中风的发病率比年龄和性别标准化的高9-12倍,55-64岁时高2-4倍;出血性卒中的发生也较高,分别为5-6倍(低于55岁)和2-3倍。采用逐步回归模型和贝叶斯模型平均的组合,缺血性卒中的最强的预测因子是心脏衰竭(比值比[OR],年龄组18-49岁:5.94(95%-Cl:3.49-10.14),年龄组50-64岁:OR 1.68(95%-Cl:1.06-2.66)),糖尿病(OR 2.33(95%-Cl:1.66-3.28))和最近发生心肌梗塞(OR 8.38(95%-Cl:1.77-39.58)) 。

在ACHD-患者中,1/11的男性和1/15的女性在18至64岁时发生卒中,卒中发生率比一般人群要高,尤其是在年轻的时候。缺血性卒中的最重要的预测因子为心脏衰竭、糖尿病和最近发生心肌梗塞。需要进一步研究来探讨ACHD管理的进步是否可以减少这种实质性的卒中发生率

原始出处:

Jonas Lanz,James M. Broph,Judith Therrien,et al.Stroke in Adults With Congenital Heart Disease: Incidence, Cumulative Risk and Predictors,Circulation,2015.11.24

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    2017-05-15 flysky120

    学习一下知识

    0

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    2017-05-10 皇家骑士团团尾

    最重要预测因子心衰 糖尿病 新发心梗

    0

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    2016-10-11 1e128d2fm65(暂无匿称)

    学习并关注,天天有长进

    0

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    2016-10-09 1e137bdcm70(暂无匿称)

    不错的文章,值得临床医生借鉴进行临床研究,这样的研究也很有意义

    0

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    2016-09-26 1e0a2178m68(暂无匿称)

    先天性心脏病要注意了,要预防脑梗塞

    0

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    2015-11-26 huirong
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