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Ann Allergy Asthma Immunol:过敏性鼻炎病人的嗜碱性粒细胞表现出了胸腺基质淋巴生成素受体的过敏原特异性上调

2018-02-19 AlexYang MedSci原创

过敏性鼻炎(AR)的诊断主要基于典型的鼻症状和过敏原敏化测试。然而,有时候在区分AR和非AR患者时具有难度,并且鉴定AR患者的起因性过敏原从而进行针对性的免疫治疗尤其困难。最近,有研究人员鉴定了AR病人之间的差异,使得受试者具有无症状的敏化作用(AS)和受试者没有过敏(NS)能够进行AR的诊断。研究发现,细胞因子受体因子2和它的产物-胸腺基质淋巴生成素受体(TSLPR)在过敏原刺激后的AR患者中的

过敏性鼻炎(AR)的诊断主要基于典型的鼻症状和过敏原敏化测试。然而,有时候在区分AR和非AR患者时具有难度,并且鉴定AR患者的起因性过敏原从而进行针对性的免疫治疗尤其困难。最近,有研究人员鉴定了AR病人之间的差异,使得受试者具有无症状的敏化作用(AS)和受试者没有过敏(NS)能够进行AR的诊断

研究发现,细胞因子受体因子2和它的产物-胸腺基质淋巴生成素受体(TSLPR)在过敏原刺激后的AR患者中的嗜碱性粒细胞中显著增加。AR受试者与AS受试者和NS受试者比较,研究人员发现了在特异性过敏原刺激后的嗜碱性粒细胞中,TSLRP-阳性细胞的比例更大。嗜碱性粒TSLPR表达在区分AR患者和AS受试者中比CD203c表达一样好或者更好,这个结果与接受者操作特征曲线一致。

最后,研究人员指出,他们的研究数据表明了TSLPR在嗜碱性粒细胞中的表达可以由过敏原刺激得到特异的上调,并且也许在鉴定AR患者的起因性过敏原中是非常有帮助的。

原始出处:


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    2018-07-26 skhzy
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createdName=ms24272190615788285182, createdTime=Wed Jun 20 01:06:00 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663484, encodeId=7158166348432, content=<a href='/topic/show?id=451a8418304' target=_blank style='color:#2F92EE;'>#胸腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84183, encryptionId=451a8418304, topicName=胸腺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fcbd25619530, createdName=1508842480_96220445, createdTime=Wed Jun 27 18:06:00 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046941, encodeId=d215204694124, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, 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objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Feb 21 13:06:00 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442617, encodeId=7f1b144261e94, content=<a href='/topic/show?id=625194032a5' target=_blank style='color:#2F92EE;'>#过敏原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94032, encryptionId=625194032a5, topicName=过敏原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=81884942400, createdName=12498cb5m14暂无昵称, createdTime=Wed Feb 21 13:06:00 CST 2018, time=2018-02-21, status=1, 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  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599441, encodeId=0ac11599441df, content=<a href='/topic/show?id=529040223bb' target=_blank style='color:#2F92EE;'>#嗜碱性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40223, encryptionId=529040223bb, topicName=嗜碱性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7aa218715508, createdName=宋威, createdTime=Wed Feb 21 13:06:00 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1899198, encodeId=fd041899198b8, content=<a href='/topic/show?id=6f746e94170' target=_blank style='color:#2F92EE;'>#特异性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67941, encryptionId=6f746e94170, topicName=特异性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc7a157, createdName=jinweidong, createdTime=Thu Sep 20 11:06:00 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757079, encodeId=bb461e5707907, content=<a href='/topic/show?id=103b421e0e8' target=_blank style='color:#2F92EE;'>#基质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42170, encryptionId=103b421e0e8, topicName=基质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=281337296540, createdName=ms7899726347904398, createdTime=Sun Nov 18 05:06:00 CST 2018, time=2018-11-18, status=1, ipAttribution=)]
    2018-03-08 半夏微凉

    阅读了谢谢

    0

  6. 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objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Feb 21 13:06:00 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442617, encodeId=7f1b144261e94, content=<a href='/topic/show?id=625194032a5' target=_blank style='color:#2F92EE;'>#过敏原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94032, encryptionId=625194032a5, topicName=过敏原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=81884942400, createdName=12498cb5m14暂无昵称, createdTime=Wed Feb 21 13:06:00 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599441, encodeId=0ac11599441df, content=<a href='/topic/show?id=529040223bb' target=_blank style='color:#2F92EE;'>#嗜碱性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40223, encryptionId=529040223bb, topicName=嗜碱性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7aa218715508, createdName=宋威, createdTime=Wed Feb 21 13:06:00 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1899198, encodeId=fd041899198b8, content=<a href='/topic/show?id=6f746e94170' target=_blank style='color:#2F92EE;'>#特异性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67941, encryptionId=6f746e94170, topicName=特异性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc7a157, createdName=jinweidong, createdTime=Thu Sep 20 11:06:00 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757079, encodeId=bb461e5707907, content=<a href='/topic/show?id=103b421e0e8' target=_blank style='color:#2F92EE;'>#基质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42170, encryptionId=103b421e0e8, topicName=基质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=281337296540, createdName=ms7899726347904398, createdTime=Sun Nov 18 05:06:00 CST 2018, time=2018-11-18, status=1, ipAttribution=)]
    2018-02-21 膀胱癌
  7. 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Allergol Immunopathol (Madr):希腊患有过敏性鼻炎儿童中的儿童睡眠习惯调查问卷研究

阻塞性呼吸系统疾病,比如过敏性鼻炎和哮喘也许会损伤睡眠质量。最近,有研究人员研究确定了儿童睡眠习惯调查问卷(CSHQ),研究对象为希腊6到14岁的儿童。到目前为止,还没有检验过的工具来评估希腊入学儿童的睡眠障碍。研究人员调查了CSHQ在一个患有过敏性鼻炎(AR)的样本中的可靠性和正确性,并且委托这些儿童的父母作为一个非临床群体,通过儿科过敏性鼻炎生活质量(PedARQol)调查问卷来间接地对儿童的

Allergol Immunopathol (Madr):在过敏性鼻炎儿童中,小气道功能紊乱发生于哮喘发生之前

流行病学证据表明了过敏性鼻炎(AR)与哮喘存在着直接的联系。一些研究同样支持了患有AR且没有哮喘的儿童中小气道功能紊乱(SAD)的存在。然而,是否SAD能够预测AR到哮喘的发展仍旧未知。最近,有研究人员探索了在非哮喘AR儿童中SAD的情况,并且评估了SAD预测哮喘的能力。研究包括了73名6岁大的儿童,他们患有间歇性的中度到重度AR,但是在前2年时间没有哮喘症状或者治疗。这些儿童经历了呼吸量测定、呼

Int Forum Allergy Rhinol:在过敏性鼻炎中,鼻通气功能是评估鼻一氧化氮诊断价值的重要因素

鼻一氧化氮(NO)在过敏性鼻炎(AR)诊断中的作用是具有争议的。最近,有研究人员在AR病人中,鉴定了能够影响鼻NO水平的因素,并且评估了鼻NO在AR诊断中的作用。研究包括了75名AR病人和31名健康对照。研究发现,鼻阻塞得分、嗜酸细胞阳离子蛋白(ECP)和鼻气道阻力(NAR)与鼻NO独立相关。鼻NO在鼻阻塞得分小于7(轻度到中度阻塞)的患者中的水平与对照相比,具有显著的增加(282.1 ± 122

Otolaryngol Head Neck Surg:单独口服抗组胺药或组合白三烯素阻断剂对过敏性鼻炎治疗的分析

最近,有研究人员评估了是否基于口服抗组胺药物(H1)的白三烯素阻断剂(LTRAs)辅助疗法能够增加过敏性鼻炎(AR)治疗的效果。数据搜索包括了 PubMed、EMBASE和CENTRAL数据库的数据,截止日期到2017年9月。那些随机对照试验(RCTs)比较了LTRAs+H1和H1治疗结果的试验是符合要求的。研究人员利用加权均数差(WMD)和95%置信区间(CI)测量了汇集比较影响,还预先设定了亚

J Allergy Clin Immunol:Dupilumab在永久过敏性鼻炎和并发哮喘中的效果和安全性评估

Dupilumab是一种抗IL-4Rα单克隆抗体,能够抑制IL-4/IL-13信号,是类型2/Th2免疫疾病的关键驱使因子(比如特应性/过敏性疾病)。在一个关键的阶段2b研究(NCT01854047)中,dupilumab能够减少重度疾病发作,改善肺功能和生活质量,虽然使用了中等剂量到高等剂量的吸入皮质激素和长效β2激动剂,但在不受控制的持续性哮喘病人中仍具有普遍良好的耐受性。最近,有研究人员探究

J Laryngol Otol:永久性过敏性鼻炎儿童标准化特异性舌下免疫治疗长期效果分析

最近,有研究人员观察和分析了永久过敏性鼻炎儿童中,单敏和多敏儿童对屋尘螨过敏的标准化特异性舌下免疫治疗5年时间的治疗效果。研究时间为2007年到2009年,包括了236名永久过敏性鼻炎的儿童,并且被分为2组:组1利用屋尘螨提取物进行了标准化的特异性舌下免疫治疗;另1个小组利用鼻用糖皮质激素和口腔抗组胺药物进行了药物治疗。研究总共包括了193名病人(106在免疫治疗小组和87名在药物治疗小组)完成了

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