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CCLM:在健康受试者中估计红细胞和网织红细胞参数的短期和中期生物学变异

2018-07-17 MedSci MedSci原创

综合评估传统和创新红细胞(RBC)和网织红细胞参数是一种快速,廉价和非侵入性的诊断工具,该方法可用于鉴别诊断和随访贫血和其他需要骨髓红细胞生成评估的病理状况。因此,估计这些参数的生物学变异(BV)对于评估血液分析仪的分析性能以及实现准确的数据解释和适当的临床管理至关重要。本研究旨在确定红细胞和网织红细胞参数的短期和中期BV估计值和参考变化值(RCV)。 研究人员使用Sysmex XN通过对2

综合评估传统和创新红细胞(RBC)和网织红细胞参数是一种快速,廉价和非侵入性的诊断工具,该方法可用于鉴别诊断和随访贫血和其他需要骨髓红细胞生成评估的病理状况。因此,估计这些参数的生物学变异(BV)对于评估血液分析仪的分析性能以及实现准确的数据解释和适当的临床管理至关重要。本研究旨在确定红细胞和网织红细胞参数的短期和中期BV估计值和参考变化值(RCV)。

研究人员使用Sysmex XN通过对21名健康志愿者评估短期BV(一次/每天一次,连续五天采血)和22名志愿者评估中期BV(一次采血/一周,连续五周)。在CV-ANOVA之前进行异常值分析,以确定具有置信区间(CI)的BV估计值。

结果分析显示,中期和短期BV分别为0.3%至16.4%和0.2-10.4%(MCHIRF),而中期和短期BV范围在0.9%至66.6%之间(MCHC)和Micro-R)和1.4-43.6%(MCHCIRF)。除血红蛋白,RDW-CVMCV外,该研究双臂的所有参数的RCV相似。

研究允许估计许多RBC和网织红细胞参数的BV,其中一些目前尚未被研究过。对于RBC,血红蛋白,RDW-CVMCV,建议根据监测时间和/或按性别区分计算RCV。关于分析目标,研究人员建议使用本研究短期内最严格的目标。

原始出处:

Buoro, Sabrina, Short- and medium-term biological variation estimates of red blood cell and reticulocyte parameters in healthy subjects

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1993810, encodeId=e6b31993810bb, content=<a href='/topic/show?id=1db6e948440' target=_blank style='color:#2F92EE;'>#网织红细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79484, encryptionId=1db6e948440, topicName=网织红细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Aug 18 22:19:00 CST 2018, time=2018-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282008, encodeId=4bd81282008b3, content=<a href='/topic/show?id=3dece71531e' target=_blank style='color:#2F92EE;'>#红细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77153, encryptionId=3dece71531e, topicName=红细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Thu Jul 19 05:19:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342502, encodeId=c2c613425024e, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Thu Jul 19 05:19:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446092, encodeId=60c21446092df, content=<a href='/topic/show?id=23f4380e5f9' target=_blank style='color:#2F92EE;'>#受试者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38075, encryptionId=23f4380e5f9, topicName=受试者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24035191312, createdName=xinmeili, createdTime=Thu Jul 19 05:19:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617869, encodeId=5bf4161e86934, content=<a href='/topic/show?id=e88f6930185' target=_blank style='color:#2F92EE;'>#生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69301, encryptionId=e88f6930185, topicName=生物学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e44019811593, createdName=12498c32m74暂无昵称, createdTime=Thu Jul 19 05:19:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332263, encodeId=04de332263d3, content=了解一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Jul 17 18:52:48 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332257, encodeId=d2c033225ecc, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Jul 17 16:28:47 CST 2018, time=2018-07-17, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1993810, encodeId=e6b31993810bb, content=<a href='/topic/show?id=1db6e948440' target=_blank style='color:#2F92EE;'>#网织红细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79484, encryptionId=1db6e948440, topicName=网织红细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Aug 18 22:19:00 CST 2018, time=2018-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282008, encodeId=4bd81282008b3, content=<a href='/topic/show?id=3dece71531e' target=_blank style='color:#2F92EE;'>#红细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77153, encryptionId=3dece71531e, topicName=红细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Thu Jul 19 05:19:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342502, encodeId=c2c613425024e, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Thu Jul 19 05:19:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446092, encodeId=60c21446092df, content=<a href='/topic/show?id=23f4380e5f9' target=_blank style='color:#2F92EE;'>#受试者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38075, encryptionId=23f4380e5f9, topicName=受试者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24035191312, createdName=xinmeili, createdTime=Thu Jul 19 05:19:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617869, encodeId=5bf4161e86934, content=<a href='/topic/show?id=e88f6930185' target=_blank style='color:#2F92EE;'>#生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69301, encryptionId=e88f6930185, topicName=生物学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e44019811593, createdName=12498c32m74暂无昵称, createdTime=Thu Jul 19 05:19:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332263, encodeId=04de332263d3, content=了解一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Jul 17 18:52:48 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332257, encodeId=d2c033225ecc, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Jul 17 16:28:47 CST 2018, time=2018-07-17, status=1, ipAttribution=)]
    2018-07-17 天地飞扬

    了解一下谢谢分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1993810, encodeId=e6b31993810bb, content=<a href='/topic/show?id=1db6e948440' target=_blank style='color:#2F92EE;'>#网织红细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79484, encryptionId=1db6e948440, topicName=网织红细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Aug 18 22:19:00 CST 2018, time=2018-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282008, encodeId=4bd81282008b3, content=<a href='/topic/show?id=3dece71531e' target=_blank style='color:#2F92EE;'>#红细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77153, encryptionId=3dece71531e, topicName=红细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Thu Jul 19 05:19:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342502, encodeId=c2c613425024e, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Thu Jul 19 05:19:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446092, encodeId=60c21446092df, content=<a href='/topic/show?id=23f4380e5f9' target=_blank style='color:#2F92EE;'>#受试者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38075, encryptionId=23f4380e5f9, topicName=受试者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24035191312, createdName=xinmeili, createdTime=Thu Jul 19 05:19:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617869, encodeId=5bf4161e86934, content=<a href='/topic/show?id=e88f6930185' target=_blank style='color:#2F92EE;'>#生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69301, encryptionId=e88f6930185, topicName=生物学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e44019811593, createdName=12498c32m74暂无昵称, createdTime=Thu Jul 19 05:19:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332263, encodeId=04de332263d3, content=了解一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Jul 17 18:52:48 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332257, encodeId=d2c033225ecc, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Jul 17 16:28:47 CST 2018, time=2018-07-17, status=1, ipAttribution=)]
    2018-07-17 1209e435m98(暂无昵称)

    学习了谢谢分享

    0

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