药品研发聚焦的十大疾病领域：癌症排名**

2017-07-21 佚名生物探索

据Analysis Group统计，截止到2016年8月，研究项目数量排名前十的依次为，癌症（Cancer）8651项，神经学(Neurology)2517项，传染病(Infections)2167项，免疫(Immunology)1601项，心血管疾病(Cardiovascular)1097项，肌肉骨骼(Musculoskeletal)963项，呼吸系统(Respiratory)930项，皮肤(S

据Analysis Group统计，截止到2016年8月，研究项目数量排名前十的依次为，癌症（Cancer）8651项，神经学(Neurology)2517项，传染病(Infections)2167项，免疫(Immunology)1601项，心血管疾病(Cardiovascular)1097项，肌肉骨骼(Musculoskeletal)963项，呼吸系统(Respiratory)930项，皮肤(Skin)822项，感觉器(Sensory organs)768项，糖尿病(Diabetes)749项。

图片来源：Endpoints News

对于那些关注药物研发趋势的人来说，癌症在新药研发项目数量中占据第一，这一点不会让人感到意外。但令人惊讶的是，肿瘤对这个行业的主导程度是前所未有的。

FDA全票推荐诺华Car-T上市，以”PD-1/PD-L1”为代表的免疫药物在癌症研究和治疗领域大放异彩。据Analysis Group提供的数据，癌症占了总pipeline项目中的8，651个，这个数字比EvaluatePharma跟踪的临床前到临床III期的24，389个项目的三分之一还要多。

同时也比排在癌症之后的5个疾病领域的综合项目还要多。排名第二的神经学领域，该领域的帕金森和阿尔茨海默症，曾经一度是制药研发的重点领域，共有468个项目，还没有进入前10。

往下游看，癌症研究占据了主导地位。3723个临床I期项目，癌症占据了近乎一半，1757个。临床II期4424个项目，1920个是癌症项目。只有在临床III期的项目中，癌症才开始失去其压倒性的优势，占1257个项目中的329个。

图片来源：Endpoints News

PhRMA撰写这份报告强调了行业在研发和重大新药开发上的投入程度。同时，该报告还提出了以下几点：

（1）四分之三的处于临床研究的项目，都在争取first-in-class地位，突显行业对可以为患者带来改变的新药的重视。Me-too的药物已经完全过时，不太可能会被买账。

（2）在所有临床阶段的项目中，822个是孤儿药，服务于20万人以下的市场。但国外孤儿药市场是一片蓝海，《孤儿药法案》等激励和促进孤儿药的研发和商业化。

（3）总共有731个细胞治疗和基因治疗项目处于临床阶段。美国FDA全票推荐诺华CAR-T疗法批准上市，是为全球首次。随着诺华（Novartis）和凯特（Kite）相继提交生物制品上市申请，美国FDA批准的首款CAR-T免疫细胞商业化疗法大概率会在2017年上市。本周，Spark Therapeutics的新药LUXTURNA也获得优先审评资格。

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2017-11-10 huanbaofeng

#药品研发#

0 0
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2018-01-26 yanjie6253_56072842

#十大疾病#

76 0
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2017-07-23 drdentist

很好

105 0
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2017-07-23 lqvr

#研发#

83 0
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2017-07-22 爱生活更爱你

不错

111 0
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2017-07-21 luominglian113

学习了，谢谢分享

90 0
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2017-07-21 虈亣靌

学习了谢谢分享

94 0
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2017-07-21 KO229256262

很好，学习了，谢谢分享

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药品研发聚焦的十大疾病领域：癌症排名**

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