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Heart:新型抗血小板药物预防复发性心肌梗死的效果分析!

2018-03-14 xing.T MedSci原创

由此可见,该研究表明新的抗血小板药物与氯吡格雷相比reMI发生明显减少,替卡格雷与首次STEMI或非STEMI更大的风险降低相关。

近日,在心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员旨在比较在现实生活中采用替卡格雷和普拉格雷治疗与氯吡格雷治疗预防复发性致命和非致命心肌梗死(reMI)的疗效。

研究人员进行了一项流行病学病例研究,病例为reMI患者,对照者为无复发事件患者。对reMI患者的ACS类型、日期、年龄和性别进行匹配。多因素条件Logistic回归评估了采用替卡格雷和普拉格雷治疗与氯吡格雷治疗后reMI的比值比和95%可信区间(HR,95%CI),调整了阿司匹林使用和心血管疾病危险因素。

该研究纳入了1047例病例和2234例匹配的对照者。与氯吡格雷相比,与替卡格雷和普拉格雷相关的reMI发生HR分别为0.65(95%CI为0.52-0.81)和0.71(95%CI为0.53-0.96)。替卡格雷和普拉格雷与氯吡格雷相比当指数ACS是第一次MI、第一次ST段抬高型MI(STEMI)、第一次非STEMI和ACS复发的比值比分别为0.50(95%CI为0.38至0.67)和0.66(95% CI 0.45至0.95),0.39(95% CI 0.24至0.62)和0.44(95% CI 0.26至0.75),0.63(95% CI 0.43至0.92)和1.20(95% CI 0.69至2.07),1.11(95% CI 0.72至1.72)和0.82(95% CI 0.44至1.54),并且在年龄≥70岁的患者中为0.63(95% CI 0.45至0.87)和0.77(95% CI 0.41至1.45)。

由此可见,该研究表明新的抗血小板药物与氯吡格雷相比reMI发生明显减少,替卡格雷与首次STEMI或非STEMI更大的风险降低相关。

原始出处:

Lamiae Grimaldi-Bensouda,et al. Effectiveness of new antiplatelets in the prevention of recurrent myocardial infarction. Heart. 2018. http://dx.doi.org/10.1136/heartjnl-2017-312534

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  5. 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topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 16 12:11:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542215, encodeId=f8c8154221513, content=<a href='/topic/show?id=d20a8e9073e' target=_blank style='color:#2F92EE;'>#药物预防#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87907, encryptionId=d20a8e9073e, topicName=药物预防)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e3b13370459, createdName=ms6829001416292975, createdTime=Fri Mar 16 12:11:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562872, encodeId=c15d15628e2aa, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 16 12:11:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296260, encodeId=1c61296260e1, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Mar 14 22:47:03 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296241, encodeId=8f8529624164, content=好好努力.继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 14 21:58:50 CST 2018, time=2018-03-14, status=1, ipAttribution=)]
    2018-03-25 杨利洪

    学习了分享一下

    0

  6. 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topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 16 12:11:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542215, encodeId=f8c8154221513, content=<a href='/topic/show?id=d20a8e9073e' target=_blank style='color:#2F92EE;'>#药物预防#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87907, encryptionId=d20a8e9073e, topicName=药物预防)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e3b13370459, createdName=ms6829001416292975, createdTime=Fri Mar 16 12:11:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562872, encodeId=c15d15628e2aa, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 16 12:11:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296260, encodeId=1c61296260e1, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Mar 14 22:47:03 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296241, encodeId=8f8529624164, content=好好努力.继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 14 21:58:50 CST 2018, time=2018-03-14, status=1, ipAttribution=)]
    2018-03-16 zhaojie88
  7. 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level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 14 21:58:50 CST 2018, time=2018-03-14, status=1, ipAttribution=)]
  8. 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topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 16 12:11:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542215, encodeId=f8c8154221513, content=<a href='/topic/show?id=d20a8e9073e' target=_blank style='color:#2F92EE;'>#药物预防#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87907, encryptionId=d20a8e9073e, topicName=药物预防)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e3b13370459, createdName=ms6829001416292975, createdTime=Fri Mar 16 12:11:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562872, encodeId=c15d15628e2aa, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 16 12:11:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296260, encodeId=1c61296260e1, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Mar 14 22:47:03 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296241, encodeId=8f8529624164, content=好好努力.继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 14 21:58:50 CST 2018, time=2018-03-14, status=1, ipAttribution=)]
    2018-03-16 slcumt
  9. 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topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 16 12:11:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542215, encodeId=f8c8154221513, content=<a href='/topic/show?id=d20a8e9073e' target=_blank style='color:#2F92EE;'>#药物预防#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87907, encryptionId=d20a8e9073e, topicName=药物预防)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e3b13370459, createdName=ms6829001416292975, createdTime=Fri Mar 16 12:11:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562872, encodeId=c15d15628e2aa, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 16 12:11:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296260, encodeId=1c61296260e1, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Mar 14 22:47:03 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296241, encodeId=8f8529624164, content=好好努力.继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 14 21:58:50 CST 2018, time=2018-03-14, status=1, ipAttribution=)]
    2018-03-14 1e1b8538m79(暂无匿称)

    不错的文章值得拥有

    0

  10. 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style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 16 12:11:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296260, encodeId=1c61296260e1, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Mar 14 22:47:03 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296241, encodeId=8f8529624164, content=好好努力.继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 14 21:58:50 CST 2018, time=2018-03-14, status=1, ipAttribution=)]
    2018-03-14 忠诚向上

    好好努力.继续学习

    0

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