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京港感染医师论坛 2013:真菌感染诊断面面观

2013-11-28 首都医科大学附属北京朝阳医院 王一民 京港感染医师论坛官网

近日,在第二届京港感染论坛真菌感染主题报告会上,空军总医院呼吸科张波主任、南京军区总医院呼吸科施毅主任、北京大学第一医院呼吸科牟向东博士分别从各自研究入手,阐释了复杂真菌感染,尤其是免疫缺陷合并多发基础疾病的患者发生侵袭性曲霉菌及肺孢子菌感染的诊断及治疗。 首先,张波主任对侵袭性曲霉菌感染的高危人群进行分析,通过对宿主因素的评价,判断引起肺部曲霉菌感染的危险因素,最终指导治疗。张波主任认为“宿主

近日,在第二届京港感染论坛真菌感染主题报告会上,空军总医院呼吸科张波主任、南京军区总医院呼吸科施毅主任、北京大学第一医院呼吸科牟向东博士分别从各自研究入手,阐释了复杂真菌感染,尤其是免疫缺陷合并多发基础疾病的患者发生侵袭性曲霉菌肺孢子菌感染的诊断及治疗。

首先,张波主任对侵袭性曲霉菌感染的高危人群进行分析,通过对宿主因素的评价,判断引起肺部曲霉菌感染的危险因素,最终指导治疗。张波主任认为“宿主免疫功能状态才是造成疾病发生、真菌感染的主要原因”但同时他也从临床病例告知感染科医师尤其是年轻医师,免疫功能缺陷患者临床情况的复杂性,常常使疾病诊断复杂化,甚至出现误诊。

然后,北京大学第一医院牟向东博士引经据典,通过自己的研究,阐明了非HIV患者肺孢子菌感染临床特征、影像学特点以及治疗经验,并勇敢对肺孢子菌应用激素治疗提出质疑。

最后,南京军区总医院呼吸科施毅教授重点分析了G试验与GM试验,类似张波教授的观点,他也将宿主免疫功能状态进行分类,从各项RCT研究及Meta分析可以看出,免疫功能低下患者,G及GM试验诊断敏感性及特异性更高。他也提出受限于目前检测方法及检测试剂的差异,G及GM试验的可靠程度可能存在一定质疑,但随着试验手段的丰富,以及组织活检的大量开展,复杂真菌感染的诊断一定不是困难。

总结三位教授充满热情的演讲,复杂真菌感染的诊断,由于临床表现、影像学及实验室检查有较大差异,因此必须充分考虑宿主不同的免疫功能,要尽可能通过组织学辅助诊断

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    2015-10-25 slicer

    xuexilr

    0

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    2013-11-30 zhaojie88
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