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EUR J Cancer:FOLFOXIRI联合贝伐单抗治疗肝脏限制性转移性结直肠癌的疗效观察

2017-12-31 MedSci MedSci原创

二次切除是治愈转移性结直肠癌(mCRC)中不能切除的肝脏限制性亚组患者的一个机会。肿瘤治疗的双重目标包括诱导肿瘤组织缩小和预防疾病的复发。FOLFOXIRI(亚叶酸,5-氟尿嘧啶,奥沙利铂和伊立替康)目前仍为一种标准化疗方案,在此研究人员分析评估了FOLFOXIRI联合贝伐单抗对肝脏限制性转移性结直肠癌的疗效,并调查了该治疗方案是否可以逆转高危患者的不良预后。

二次切除是治愈转移性结直肠癌(mCRC)中不能切除的肝脏限制性亚组患者的一个机会。肿瘤治疗的双重目标包括诱导肿瘤组织缩小和预防疾病的复发。FOLFOXIRI(亚叶酸,5-氟尿嘧啶,奥沙利铂和伊立替康)目前仍为一种标准化疗方案,在此研究人员分析评估了FOLFOXIRI联合贝伐单抗对肝脏限制性转移性结直肠癌的疗效,并调查了该治疗方案是否可以逆转高危患者的不良预后。

541例患者中,有205例(37.9%)为肝脏限制性mCRC74名患者(36.1%)接受了转移瘤的R0R1切除。17名患者(8.3%)接受了R2切除。在单变量和多变量分析中,相比于其他患者,R0 / R1切除的患者具有显著延长的中位无进展生存期(PFS)(18.1 vs 10.7个月,HR0.48 [0.35-0.66]p <0.001)和总生存期(OS)(44.3 vs 24.4个月,HR0.32 [0.22-0.48]P <0.001)。R0切除的患者的5PFSOS率分别为12%43%

综上所述,综合长期试验结果和预后因素,FOLFOXIRI联合贝伐单抗治疗肝脏限制性转移性结直肠癌是安全有效的。 

原始出处:

Cremolini, Chiara, et al. "Efficacy of FOLFOXIRI plus bevacizumab in liver-limited metastatic colorectal cancer: A pooled analysis of clinical studies by Gruppo Oncologico del Nord Ovest." European Journal of Cancer 2017 73: 74-84. doi.org/10.1016/j.ejca.

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