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Ann Pharmacother：甘露醇可能减轻顺铂的肾毒性风险

2014-07-26 MedSci MedSci原创

甘露醇顺铂
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    顺铂是一种应用广泛的抗肿瘤药物。其主要副作用之一是剂量限制性肾毒性。目前有很多方法可以防止这种毒性的发生，如作为肾防护剂的甘露醇联合水合作用等。以前也有不少研究认为短期脱水治疗，能够减少顺铂引发的肾毒性风险。Morgan KP是国际这方面的权威专家。 美国学者Morgan KP研究发现甘露醇数量有限的情况下，应该优先考虑给予有罹患肾毒性高风险

    
顺铂是一种应用广泛的抗肿瘤药物。其主要副作用之一是剂量限制性肾毒性。目前有很多方法可以防止这种毒性的发生，如作为肾防护剂的甘露醇联合水合作用等。以前也有不少研究认为短期脱水治疗，能够减少顺铂引发的肾毒性风险。Morgan KP是国际这方面的权威专家。

美国学者Morgan KP研究发现甘露醇数量有限的情况下，应该优先考虑给予有罹患肾毒性高风险的患者。接受顺铂每3周1次100 mg/m2给药方案的患者和并发高血压的患者发生肾毒性的风险最高，添加应用甘露醇可使这类患者受益。论文2014年5月在线发表于《药物治疗年鉴》(The Annals of Pharmacotherapy)。

该研究由国家甘露醇短缺组织创建;数据来自于2011年1月至2012年9月接受顺铂单药治疗的门诊成人患者;主要结果是急性肾损伤(AKI)。

结果如下：

  • 共评估143例接受顺铂单药治疗的患者，其中97.2%的患者主要肿瘤位于头颈部。
  • 未接受甘露醇的患者更可能发生肾毒性：优势比[OR] = 2.646 (95% CI = 1.008, 6.944; P = 0.048)。
  • 接受顺铂剂量为100 mg/m2的患者和有高血压病史的患者发生肾毒性的可能性也较高，优势比[OR]分别为11.494 (95% CI = 4.149, 32.258; P < 0.0001)和3.219 (95% CI = 1.228, 8.439; P = 0.017)。

原始出处：

Morgan KP, Snavely AC, Wind LS, Buie LW, Grilley-Olson J, Walko CM, Weiss J.Rates of Renal Toxicity in Cancer Patients Receiving Cisplatin With and Without Mannitol.Ann Pharmacother. 2014 Apr 28;48(7):863-869.

Horinouchi H, Kubota K, Itani H, Taniyama TK, Nakamichi S, Wakui H, Kanda S, Nokihara H, Yamamoto N, Sekine I, Tamura T.Short hydration in chemotherapy containing cisplatin (≥75 mg/m2) for patients with lung cancer: a prospective study.Jpn J Clin Oncol. 2013 Nov;43(11):1105-9

Muraki K, Koyama R, Honma Y, Yagishita S, Shukuya T, Ohashi R, Takahashi F, Kido K, Iwakami S, Sasaki S, Iwase A, Takahashi K.Hydration with magnesium and mannitol without furosemide prevents the nephrotoxicity induced by cisplatin and pemetrexed in patients with advanced non-small cell lung cancer.J Thorac Dis. 2012 Dec;4(6):562-8.

Morgan KP, Buie LW, Savage SW.The role of mannitol as a nephroprotectant in patients receiving cisplatin therapy.Ann Pharmacother. 2012 Feb;46(2):276-81

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    2015-06-30 yb6560

    #MAC#

    0

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    2014-08-13 jj000001

    #Pharm#

    0

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    2014-10-11 ms3153534357578991

    #铂#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1995905, encodeId=46f81995905e5, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Jun 30 12:04:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787153, encodeId=bbe11e8715318, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Wed Aug 13 03:04:00 CST 2014, time=2014-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1737466, encodeId=4a741e374660c, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Sat Oct 11 07:04:00 CST 2014, time=2014-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=11191, encodeId=517b11191f5, content=我们化疗都在用甘露醇保护肾脏！, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f3fd107127, createdName=wutongshulyl, createdTime=Wed Aug 20 21:00:00 CST 2014, time=2014-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908172, encodeId=4edd19081e2ff, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sun Mar 01 05:04:00 CST 2015, time=2015-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10938, encodeId=f1bb10938df, content=甘露醇！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=176, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5757106889, createdName=oubaochi, createdTime=Wed Aug 06 16:30:00 CST 2014, time=2014-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295669, encodeId=b8cc129566903, content=<a href='/topic/show?id=e02468846d4' target=_blank style='color:#2F92EE;'>#甘露醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68846, encryptionId=e02468846d4, topicName=甘露醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Mon Jul 28 11:04:00 CST 2014, time=2014-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438954, encodeId=7f9a1438954a0, content=<a href='/topic/show?id=3e168256551' target=_blank style='color:#2F92EE;'>#肾毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82565, encryptionId=3e168256551, topicName=肾毒性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Mon Jul 28 11:04:00 CST 2014, time=2014-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10667, encodeId=43b61066ef9, content=这个研究很有临床价值，但需要更高质量的临床研究验证, beContent=null, objectType=article, channel=null, level=null, likeNumber=192, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=114.90.53.74, createdTime=Sat Jul 26 21:44:00 CST 2014, time=2014-07-26, status=1, ipAttribution=)]
    2014-08-20 wutongshulyl

    我们化疗都在用甘露醇保护肾脏！

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1995905, encodeId=46f81995905e5, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Jun 30 12:04:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787153, encodeId=bbe11e8715318, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Wed Aug 13 03:04:00 CST 2014, time=2014-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1737466, encodeId=4a741e374660c, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Sat Oct 11 07:04:00 CST 2014, time=2014-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=11191, encodeId=517b11191f5, content=我们化疗都在用甘露醇保护肾脏！, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f3fd107127, createdName=wutongshulyl, createdTime=Wed Aug 20 21:00:00 CST 2014, time=2014-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908172, encodeId=4edd19081e2ff, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sun Mar 01 05:04:00 CST 2015, time=2015-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10938, encodeId=f1bb10938df, content=甘露醇！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=176, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5757106889, createdName=oubaochi, createdTime=Wed Aug 06 16:30:00 CST 2014, time=2014-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295669, encodeId=b8cc129566903, content=<a href='/topic/show?id=e02468846d4' target=_blank style='color:#2F92EE;'>#甘露醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68846, encryptionId=e02468846d4, topicName=甘露醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Mon Jul 28 11:04:00 CST 2014, time=2014-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438954, encodeId=7f9a1438954a0, content=<a href='/topic/show?id=3e168256551' target=_blank style='color:#2F92EE;'>#肾毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82565, encryptionId=3e168256551, topicName=肾毒性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Mon Jul 28 11:04:00 CST 2014, time=2014-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10667, encodeId=43b61066ef9, content=这个研究很有临床价值，但需要更高质量的临床研究验证, beContent=null, objectType=article, channel=null, level=null, likeNumber=192, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=114.90.53.74, createdTime=Sat Jul 26 21:44:00 CST 2014, time=2014-07-26, status=1, ipAttribution=)]
    2015-03-01 chentianping

    #pharma#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1995905, encodeId=46f81995905e5, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Jun 30 12:04:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787153, encodeId=bbe11e8715318, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Wed Aug 13 03:04:00 CST 2014, time=2014-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1737466, encodeId=4a741e374660c, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Sat Oct 11 07:04:00 CST 2014, time=2014-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=11191, encodeId=517b11191f5, content=我们化疗都在用甘露醇保护肾脏！, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f3fd107127, createdName=wutongshulyl, createdTime=Wed Aug 20 21:00:00 CST 2014, time=2014-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908172, encodeId=4edd19081e2ff, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sun Mar 01 05:04:00 CST 2015, time=2015-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10938, encodeId=f1bb10938df, content=甘露醇！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=176, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5757106889, createdName=oubaochi, createdTime=Wed Aug 06 16:30:00 CST 2014, time=2014-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295669, encodeId=b8cc129566903, content=<a href='/topic/show?id=e02468846d4' target=_blank style='color:#2F92EE;'>#甘露醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68846, encryptionId=e02468846d4, topicName=甘露醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Mon Jul 28 11:04:00 CST 2014, time=2014-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438954, encodeId=7f9a1438954a0, content=<a href='/topic/show?id=3e168256551' target=_blank style='color:#2F92EE;'>#肾毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82565, encryptionId=3e168256551, topicName=肾毒性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Mon Jul 28 11:04:00 CST 2014, time=2014-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10667, encodeId=43b61066ef9, content=这个研究很有临床价值，但需要更高质量的临床研究验证, beContent=null, objectType=article, channel=null, level=null, likeNumber=192, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=114.90.53.74, createdTime=Sat Jul 26 21:44:00 CST 2014, time=2014-07-26, status=1, ipAttribution=)]
    2014-08-06 oubaochi

    甘露醇！！！

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1995905, encodeId=46f81995905e5, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Jun 30 12:04:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787153, encodeId=bbe11e8715318, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Wed Aug 13 03:04:00 CST 2014, time=2014-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1737466, encodeId=4a741e374660c, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Sat Oct 11 07:04:00 CST 2014, time=2014-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=11191, encodeId=517b11191f5, content=我们化疗都在用甘露醇保护肾脏！, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f3fd107127, createdName=wutongshulyl, createdTime=Wed Aug 20 21:00:00 CST 2014, time=2014-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908172, encodeId=4edd19081e2ff, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sun Mar 01 05:04:00 CST 2015, time=2015-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10938, encodeId=f1bb10938df, content=甘露醇！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=176, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5757106889, createdName=oubaochi, createdTime=Wed Aug 06 16:30:00 CST 2014, time=2014-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295669, encodeId=b8cc129566903, content=<a href='/topic/show?id=e02468846d4' target=_blank style='color:#2F92EE;'>#甘露醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68846, encryptionId=e02468846d4, topicName=甘露醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Mon Jul 28 11:04:00 CST 2014, time=2014-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438954, encodeId=7f9a1438954a0, content=<a href='/topic/show?id=3e168256551' target=_blank style='color:#2F92EE;'>#肾毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82565, encryptionId=3e168256551, topicName=肾毒性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Mon Jul 28 11:04:00 CST 2014, time=2014-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10667, encodeId=43b61066ef9, content=这个研究很有临床价值，但需要更高质量的临床研究验证, beContent=null, objectType=article, channel=null, level=null, likeNumber=192, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=114.90.53.74, createdTime=Sat Jul 26 21:44:00 CST 2014, time=2014-07-26, status=1, ipAttribution=)]
    2014-07-28 medscijoin

    #甘露醇#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1995905, encodeId=46f81995905e5, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Jun 30 12:04:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787153, encodeId=bbe11e8715318, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Wed Aug 13 03:04:00 CST 2014, time=2014-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1737466, encodeId=4a741e374660c, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Sat Oct 11 07:04:00 CST 2014, time=2014-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=11191, encodeId=517b11191f5, content=我们化疗都在用甘露醇保护肾脏！, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f3fd107127, createdName=wutongshulyl, createdTime=Wed Aug 20 21:00:00 CST 2014, time=2014-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908172, encodeId=4edd19081e2ff, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sun Mar 01 05:04:00 CST 2015, time=2015-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10938, encodeId=f1bb10938df, content=甘露醇！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=176, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5757106889, createdName=oubaochi, createdTime=Wed Aug 06 16:30:00 CST 2014, time=2014-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295669, encodeId=b8cc129566903, content=<a href='/topic/show?id=e02468846d4' target=_blank style='color:#2F92EE;'>#甘露醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68846, encryptionId=e02468846d4, topicName=甘露醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Mon Jul 28 11:04:00 CST 2014, time=2014-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438954, encodeId=7f9a1438954a0, content=<a href='/topic/show?id=3e168256551' target=_blank style='color:#2F92EE;'>#肾毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82565, encryptionId=3e168256551, topicName=肾毒性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Mon Jul 28 11:04:00 CST 2014, time=2014-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10667, encodeId=43b61066ef9, content=这个研究很有临床价值，但需要更高质量的临床研究验证, beContent=null, objectType=article, channel=null, level=null, likeNumber=192, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=114.90.53.74, createdTime=Sat Jul 26 21:44:00 CST 2014, time=2014-07-26, status=1, ipAttribution=)]
    2014-07-28 仁医06

    #肾毒性#

    0

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    2014-07-26 114.90.53.74

    这个研究很有临床价值，但需要更高质量的临床研究验证

    0

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