Clin Chem：循环肿瘤细胞作为复发或转移性头颈部鳞状细胞癌的预后因素？

2019-10-23 MedSci MedSci原创

本前瞻性多中心研究评估了循环肿瘤细胞(CTCs)在复发、非手术或转移性头颈鳞癌(rHNSCC)化疗和西妥昔单抗治疗中的预后价值。

本前瞻性多中心研究评估了循环肿瘤细胞(CTCs)在复发、非手术或转移性头颈鳞癌(rHNSCC)化疗和西妥昔单抗治疗中的预后价值。

研究人员对65例适合分析的患者分别于治疗第0天(D0)、第7天、第21天取外周血，采用CellSearch®、EPISPOT、流式细胞术(FCM)检测CTC。采用Kaplan-Meier法评估PFS，并与log-rank检验比较(P < 0.05)。

研究发现，在D₀时，使用EPISPOT、CellSearch和FCM可分别检测出69%(45/65)、21%(12/58)和11%(7/61)的ctc。在所有3种方法检测的患者中，EPISPOT分别在D₀、D₇和D₂₁的阳性样本中识别92%(36/39)、92%(35/38)和90%(25/28)。在(a) CTC计数从D₀增加到D₇或EPISPOT^EGFR稳定(36/54)的患者(3.9个月vs 6.2个月;95%置信区间,5.0 - -6.9;P = 0.0103)和(b)使用EPISPOT或CellSearch®(37/51)(P = 0.0311)、EPISPOT或FCM (38/54) (P = 0.0480)和CellSearch或FCM (11/51) (P = 0.0005)检测≥1 CTC的患者(P = 0.0103)PFS中位数时间显著较低。

研究表明，rHNSCC患者化疗前后均可检测到CTCs。用EPISPOT^EGFR评价的D₀-D₇ CTC动力学与治疗反应相关。本研究提示CTCs可作为实时液体活检来监测rHNSCC早期化疗反应。

原始出处：

Renaud Garrel, Martine Mazel,Circulating Tumor Cells as a Prognostic Factor in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: The CIRCUTEC Prospective Study

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2020-05-16 qingting

#细胞癌#

45 0
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2019-10-25 Smile2680

#头颈部鳞状细胞癌#

58 0
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2019-10-25 hmwwww

#肿瘤细胞#

67 0
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2019-10-25 1249842em09(暂无昵称)

#转移性#

58 0
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2019-10-25 ms2536978994064944

#预后因素#

42 0
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2019-10-25 wshxjq

#头颈部#

103 0
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2019-10-25 thinkibmz_44722599

#循环肿瘤细胞#

54 0
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2019-10-25 仁心济世

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