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JAMA Neurol：视网膜神经纤维层厚度与认知衰退

2018-06-27 zhangfan MedSci原创

认知痴呆视网膜神经纤维层厚度
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研究认为，对于无神经退行性疾病人群，较薄的视网膜神经纤维层厚度与认知能力较差以及后继认知能力衰退相关

认知衰退是痴呆的先兆，近日研究人员在健康人群中考察了视网膜神经纤维层(RNFL) 厚度测量对认知衰退风险的预测效果。

40-69岁人群接受了视网膜光学相干断层成像、体格检查和问卷调查。参与者基线进行了4项基本认知测试，大约3年后，重复这些测试。通过多变量逻辑回归模型考察RNFL厚度与认知功能的相关性。重点考察基线认知测试得分最低1/5人群以及随访认知得分显著降低人群。

总计32038名参与者，平均年龄56.0岁，女性占53.6%。基线时，RNFL较薄人群的认知表现较差。多变量分析显示RNFL厚度最薄1/5人群，其至少1项认知测试失败的可能性增加11%。1251名参与者接受了3年后随访，RNFL厚度最薄1/5-2/5人群其至少一项认知评分显著降低的风险增加2倍（RNFL厚度最薄2/5风险比值比为1.92，最薄1/5人群的风险比值比为2.08）。

研究认为，对于无神经退行性疾病人群，较薄的视网膜神经纤维层厚度与认知能力较差以及后继认知能力衰退相关。

原始出处：


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    2018-08-03 徐岩

    #视网膜神经#

    0

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    2018-07-03 ssnine

    #视网膜神经纤维层厚度#

    0

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    2018-08-14 yinhl1978

    #Neurol#

    0

  4. 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createdBy=25c8396, createdName=ssnine, createdTime=Tue Jul 03 16:14:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000480, encodeId=3c9220004806a, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Aug 14 06:14:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804484, encodeId=5b721804484b9, content=<a href='/topic/show?id=0df6e7240df' target=_blank style='color:#2F92EE;'>#纤维层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77240, encryptionId=0df6e7240df, topicName=纤维层)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Fri Aug 31 12:14:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270074, encodeId=880812e0074eb, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Fri Jun 29 03:14:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489755, encodeId=10a01489e557c, content=<a href='/topic/show?id=5293e447259' target=_blank style='color:#2F92EE;'>#神经纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74472, encryptionId=5293e447259, topicName=神经纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53f28597470, createdName=stfoxst, createdTime=Fri Jun 29 03:14:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553686, encodeId=07f11553686d3, content=<a href='/topic/show?id=52399126814' target=_blank style='color:#2F92EE;'>#认知衰退#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91268, encryptionId=52399126814, topicName=认知衰退)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c45614401041, createdName=朱睿睿, createdTime=Fri Jun 29 03:14:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327441, encodeId=4d1132e441bd, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epLWLHOOeaLiabibyplZBrSPxxnWVR7dHMFsIgbXGnsulAjGv3AaicTYUvNdll7QLqeFERqBKbReQ0VQ/132, createdBy=f6471852173, createdName=毛毛阳阳, createdTime=Wed Jun 27 13:06:52 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327434, encodeId=5add32e434c5, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Wed Jun 27 12:57:14 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327431, encodeId=25f832e43147, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jun 27 12:56:35 CST 2018, time=2018-06-27, status=1, ipAttribution=)]
    2018-08-31 amyloid

    #纤维层#

    0

  5. 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createdBy=25c8396, createdName=ssnine, createdTime=Tue Jul 03 16:14:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000480, encodeId=3c9220004806a, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Tue Aug 14 06:14:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804484, encodeId=5b721804484b9, content=<a href='/topic/show?id=0df6e7240df' target=_blank style='color:#2F92EE;'>#纤维层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77240, encryptionId=0df6e7240df, topicName=纤维层)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Fri Aug 31 12:14:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270074, encodeId=880812e0074eb, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Fri Jun 29 03:14:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489755, encodeId=10a01489e557c, content=<a href='/topic/show?id=5293e447259' target=_blank style='color:#2F92EE;'>#神经纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74472, encryptionId=5293e447259, topicName=神经纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53f28597470, createdName=stfoxst, createdTime=Fri Jun 29 03:14:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553686, encodeId=07f11553686d3, content=<a href='/topic/show?id=52399126814' target=_blank style='color:#2F92EE;'>#认知衰退#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91268, encryptionId=52399126814, topicName=认知衰退)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c45614401041, createdName=朱睿睿, createdTime=Fri Jun 29 03:14:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327441, encodeId=4d1132e441bd, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epLWLHOOeaLiabibyplZBrSPxxnWVR7dHMFsIgbXGnsulAjGv3AaicTYUvNdll7QLqeFERqBKbReQ0VQ/132, createdBy=f6471852173, createdName=毛毛阳阳, createdTime=Wed Jun 27 13:06:52 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327434, encodeId=5add32e434c5, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Wed Jun 27 12:57:14 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327431, encodeId=25f832e43147, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jun 27 12:56:35 CST 2018, time=2018-06-27, status=1, ipAttribution=)]
    2018-06-29 zutt

    #视网膜#

    0

  6. 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topicList=[TopicDto(id=77240, encryptionId=0df6e7240df, topicName=纤维层)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Fri Aug 31 12:14:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270074, encodeId=880812e0074eb, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Fri Jun 29 03:14:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489755, encodeId=10a01489e557c, content=<a href='/topic/show?id=5293e447259' target=_blank style='color:#2F92EE;'>#神经纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74472, encryptionId=5293e447259, topicName=神经纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53f28597470, createdName=stfoxst, createdTime=Fri Jun 29 03:14:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553686, encodeId=07f11553686d3, content=<a href='/topic/show?id=52399126814' target=_blank style='color:#2F92EE;'>#认知衰退#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91268, encryptionId=52399126814, topicName=认知衰退)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c45614401041, createdName=朱睿睿, createdTime=Fri Jun 29 03:14:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327441, encodeId=4d1132e441bd, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epLWLHOOeaLiabibyplZBrSPxxnWVR7dHMFsIgbXGnsulAjGv3AaicTYUvNdll7QLqeFERqBKbReQ0VQ/132, createdBy=f6471852173, createdName=毛毛阳阳, createdTime=Wed Jun 27 13:06:52 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327434, encodeId=5add32e434c5, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Wed Jun 27 12:57:14 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327431, encodeId=25f832e43147, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jun 27 12:56:35 CST 2018, time=2018-06-27, status=1, ipAttribution=)]
    2018-06-29 stfoxst

    #神经纤维#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1801565, encodeId=1c0b180156541, content=<a href='/topic/show?id=9cd690e860a' target=_blank style='color:#2F92EE;'>#视网膜神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90786, encryptionId=9cd690e860a, topicName=视网膜神经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Fri Aug 03 12:14:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2018089, encodeId=d58820180896f, content=<a href='/topic/show?id=8adc90e9115' target=_blank style='color:#2F92EE;'>#视网膜神经纤维层厚度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90791, encryptionId=8adc90e9115, topicName=视网膜神经纤维层厚度)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicList=[TopicDto(id=77240, encryptionId=0df6e7240df, topicName=纤维层)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Fri Aug 31 12:14:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270074, encodeId=880812e0074eb, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Fri Jun 29 03:14:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489755, encodeId=10a01489e557c, content=<a href='/topic/show?id=5293e447259' target=_blank style='color:#2F92EE;'>#神经纤维#</a>, beContent=null, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327431, encodeId=25f832e43147, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jun 27 12:56:35 CST 2018, time=2018-06-27, status=1, ipAttribution=)]
    2018-06-29 朱睿睿

    #认知衰退#

    0

  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327431, encodeId=25f832e43147, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jun 27 12:56:35 CST 2018, time=2018-06-27, status=1, ipAttribution=)]
    2018-06-27 毛毛阳阳

    学习了

    0

  9. 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    2018-06-27 wzb521zf

    一起学习学习

    0

  10. 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    2018-06-27 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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研究发现，痴呆风险高的健康人群其执行控制操作，视觉感知与建构能力下降，其下降程度与APOE基因型、脑白质病变以及阿尔兹海默标志物相关

Clin Gastroenterol H：使用PPI会导致认知功能下降吗？

2018年5月，发表于《Clin Gastroenterol Hepatol》上的一项研究，表明了质子泵抑制剂（PPI）的使用和认知功能下降之间缺乏相关性。

Nat Commun：戴眼镜的人似乎更聪明？超大型研究：确定了148个影响一般认知功能的基因位点

一般而言，戴眼镜的人看上去会比较“有学问”，有学问自然就会聪明。真的是这样吗？近日，一项新的研究证实，戴眼镜的人或许还真的比视力正常的人聪明。近日发表在《Nature Communications》上的一项迄今为止最大型的认知功能遗传学研究揭示了智力与视力有显着联系。这项研究由来自世界各地的研究人员共同完成，包括澳大利亚、奥地利、克罗地亚、芬兰、法国、德国、荷兰、冰岛、爱尔兰、挪威、瑞典以及美国。

Clin Interv Aging：耳蜗移植能够改善老年人口的神经认知么？

之前的研究将认知和听力的能力之间的关系已经阐释的很清楚。由于人口统计资料的变化，患有感官听力损失和认知障碍的人口数量正在增加。最近，有研究人员鉴定了通过耳蜗移植的听力重建对老年人口认知减退的影响。研究包括了60名参与者，年龄在50岁到84之间（平均年龄65.8岁，SD=8.9），他们具有重度或者永久性的双边听力损伤。在耳蜗移植前和移植后6个月以及12个月，研究人员基于计算机评估了短期和长期记忆、处

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