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Gastric Cancer:胃癌的代谢产物可以预测腹膜复发

2020-04-14 MedSci原创 MedSci原创

代谢组学可用于分析癌症进展所需的营养状况,本项研究评估了胃癌(GC)组织的代谢组学概况,以阐明代谢与癌症复发之间的关联。

背景:代谢组学可用于分析癌症进展所需的营养状况,本项研究评估了胃癌(GC)组织的代谢组学概况,以阐明代谢与癌症复发之间的关联。

方法:研究人员从140例行胃切除术的GC患者中获得癌症和相邻的非癌组织标本。将冷冻的组织匀浆并通过毛细管电泳飞行时间质谱(CE-TOFMS)进行分析。根据是否存在复发进一步评估癌症患者的代谢产物。

结果:研究人员共定量分析了九十三种代谢物。与非癌组织相比,在癌组织中,乳酸水平显着较高,腺苷酸能电荷较低。复发患者的Asp,β-Ala,GDP和Gly水平显着低于无复发患者。根据ROC分析确定四种代谢物的临界值,将患者分为腹膜复发的高风险和低风险组。Logistic回归和Cox比例风险分析确定β-丙氨酸是腹膜复发的独立预测因子([HR] 5.21 [95%置信区间1.07-35.89],p=0.029)和整体生存的独立预后因素(HR 3.44 [95%CI 1.65-7.14],p<0.001)。

结论:癌组织的代谢组学谱与非癌组织的代谢组学谱不同。另外β-丙氨酸既是腹膜复发的重要预测指标,也是预后因素。

原始出处:

Sanae Kaji. Et al. Metabolomic profiling of gastric cancer tissues identified potential biomarkers for predicting peritoneal recurrence. Gastric Cancer .2020.

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    2020-11-29 许安
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    2020-12-01 skhzy
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    2020-04-16 xuyong530

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