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Biofactors:研究发现Zg有益于治疗骨和骨相关疾病

2019-05-25 不详 网络

据报道,从姜中分离的酚类化合物姜油酮4-(4-羟基-3-甲氧基苯基)-2-丁酮(Zg)具有抗炎和抗糖尿病特性。 然而,其在促进骨生成中的作用尚不清楚。 在这项研究中,我们研究了Zg在细胞和分子水平上对骨生成的治疗效果。Zg处理对小鼠间充质干细胞(mMSC)无毒。在细胞水平,它增强了成骨细胞的分化,这可以通过更多的钙沉积来证明。在分子水平上,Zg刺激mMSC中Runx2(骨转录因子)和成骨细胞分化的

据报道,从姜中分离的酚类化合物姜油酮4-(4-羟基-3-甲氧基苯基)-2-丁酮(Zg)具有抗炎和抗糖尿病特性。 然而,其在促进骨生成中的作用尚不清楚。

在这项研究中,我们研究了Zg在细胞和分子水平上对骨生成的治疗效果。Zg处理对小鼠间充质干细胞(mMSC)无毒。在细胞水平,它增强了成骨细胞的分化,这可以通过更多的钙沉积来证明。在分子水平上,Zg刺激mMSC中Runx2(骨转录因子)和成骨细胞分化的其他标记基因的表达。最近的研究表明microRNAs(miRNAs)调节骨代谢,我们发现mMSCs中的Zg处理通过靶向Smad7(TGF-β1信号传导的拮抗剂)上调mir-590,一种Runx2的正调节因子。

因此,Zg的成骨潜力将有益于治疗骨和骨相关疾病。

原始出处:

Srinaath N, Balagangadharan K, et al., Osteogenic potential of zingerone, a phenolic compound in mouse mesenchymal stem cells. Biofactors. 2019 May 15. doi: 10.1002/biof.1515.

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    2019-12-12 gao_jian4217
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    2019-12-18 sunylz
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1753478, encodeId=4fe81e53478e7, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Mon Jan 20 21:11:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862778, encodeId=fca01862e7836, content=<a href='/topic/show?id=0b69542242' target=_blank style='color:#2F92EE;'>#CTO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5422, encryptionId=0b69542242, topicName=CTO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c66088, createdName=gao_jian4217, createdTime=Thu Dec 12 16:11:00 CST 2019, time=2019-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918709, encodeId=b6bf1918e092b, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Dec 18 09:11:00 CST 2019, time=2019-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956773, encodeId=7a6b1956e73e1, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Thu Jul 11 23:11:00 CST 2019, time=2019-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394694, encodeId=bc85139469496, content=<a href='/topic/show?id=8b5fe21212' target=_blank style='color:#2F92EE;'>#factor#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7212, encryptionId=8b5fe21212, topicName=factor)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e62500168, createdName=ms1774076774505970, createdTime=Mon May 27 13:11:00 CST 2019, time=2019-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626090, encodeId=e018162609033, content=<a href='/topic/show?id=09b2e21499' target=_blank style='color:#2F92EE;'>#factors#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7214, encryptionId=09b2e21499, topicName=factors)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4fbd20968813, createdName=huiwelcome, createdTime=Mon May 27 13:11:00 CST 2019, time=2019-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366785, encodeId=a56b366e8546, content=学习,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun May 26 00:00:35 CST 2019, time=2019-05-26, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1753478, encodeId=4fe81e53478e7, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Mon Jan 20 21:11:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862778, encodeId=fca01862e7836, content=<a href='/topic/show?id=0b69542242' target=_blank style='color:#2F92EE;'>#CTO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5422, encryptionId=0b69542242, topicName=CTO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c66088, createdName=gao_jian4217, createdTime=Thu Dec 12 16:11:00 CST 2019, time=2019-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918709, encodeId=b6bf1918e092b, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Dec 18 09:11:00 CST 2019, time=2019-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956773, encodeId=7a6b1956e73e1, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Thu Jul 11 23:11:00 CST 2019, time=2019-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394694, encodeId=bc85139469496, content=<a href='/topic/show?id=8b5fe21212' target=_blank style='color:#2F92EE;'>#factor#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7212, encryptionId=8b5fe21212, topicName=factor)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e62500168, createdName=ms1774076774505970, createdTime=Mon May 27 13:11:00 CST 2019, time=2019-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626090, encodeId=e018162609033, content=<a href='/topic/show?id=09b2e21499' target=_blank style='color:#2F92EE;'>#factors#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7214, encryptionId=09b2e21499, topicName=factors)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4fbd20968813, createdName=huiwelcome, createdTime=Mon May 27 13:11:00 CST 2019, time=2019-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366785, encodeId=a56b366e8546, content=学习,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun May 26 00:00:35 CST 2019, time=2019-05-26, status=1, ipAttribution=)]
    2019-05-26 天地飞扬

    学习,谢谢分享!

    0

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