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Bri J Anaesth:小于1 MAC的地氟醚对气管插管诱发的QT间期的影响

2018-02-11 符校魁 “罂粟花”微信号

丙泊酚麻醉诱导后控制通气时吸入1MAC的地氟醚不影响气管插管引起的QTc延长。

背景与目的

地氟醚的最低有效肺泡浓度(MAC)已被证明可延长QT间期,但尚不清楚在较低浓度下是否也是这种情况。 本研究的目的是确定地氟醚浓度<1MAC是否影响气管插管诱导的QT间期延长。

方  法

四十四个受试者接受吸入1 MAC地氟烷,氧气100%,新鲜气体流速为6升/分钟(地氟醚组)或仅有氧气100%(对照组)。开始于异丙酚麻醉诱导,气管插管。 QT间隔由Bazett(QTcB)和Fridericia(QTcF)公式校正。 主要测量结果是气管插管后QTcB。 次要结果是T波峰值(Tp-e),平均动脉压(MAP),心率(HR)和双频指数(BIS)评分。

结  果

气管插管后即刻QTc间期在对照组和地氟烷组之间没有差异。 本研究中两组间Tp-e或HR无差异。 然而,在气管插管后1分钟,地氟醚组的MAP和BIS评分明显降低。

结  论

丙泊酚麻醉诱导后控制通气时吸入1MAC的地氟醚不影响气管插管引起的QTc延长。

原始出处:

Kim S H, Park S Y, Chae W S, et al. Effect of desflurane at less than 1 MAC on QT interval prolongation induced by tracheal intubation.[J]. British Journal of Anaesthesia, 2010, 104(2):150-157.

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    2018-11-15 yb6560
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    2018-10-17 AspirantSuo
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    2018-04-27 lsj628
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    2018-02-11 1dd8c52fm63(暂无匿称)

    了解了解.学习学习

    0

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