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BMJ:长期麸质摄入与冠心病风险有关吗?

2017-05-04 xing.T MedSci原创

由此可见,长期摄入麸质与冠心病风险无关。然而,避免麸质可能会导致有益的全谷物摄入减少,这可能会影响心血管风险,在无乳糜泻的患者中不鼓励无麸质饮食。

近日,顶级杂志BMJ上发表了一篇研究文章,研究人员旨在探讨长期摄入麸质与冠心病发生发展之间的关系。

该研究采用前瞻性队列研究设计,以64714名护士健康研究中的女性参与者和45303名健康专业随访研究中的无冠心病病史的男性参与者为基础,这些参与者在1986年完成了131项半定量食物频率问卷,并且每4年更新一次,直至2010年。研究人员通过食物频率问卷估计了麸质的摄入量。该研究的主要结局指标为冠心病(致死性或非致死性心肌梗死)的发生。

在26年的随访期间,共有2273931人次每年,其中2431名女性和4098名男性参与者患上了冠心病。相比于麸质的摄入量为最低第五名的参与者,其冠心病的发病率为352人每100000人每年,那些麸质的摄入量为最高第五名的参与者冠心病的发病率为277人每100000人每年,导致未经调整的发生率差异为75(95%可信区间为51-98)人每100000人每年。对已知的危险因素进行调整后,麸质的摄入量为最高第五名的参与者发生冠心病多变量的风险比为0.95(95%可信区间为0.88-1.02;趋势P=0.29)。对摄入全谷物进行额外的调整后,多元风险比为1(0.92-1.09;趋势P=0.77)。相反,对精制谷物摄入进行额外的调整后,估计的麸质摄入量与冠心病的风险降低相关(多元风险比为0.85,0.77-0.93;趋势P=0.002)。

由此可见,长期摄入麸质与冠心病风险无关。然而,避免麸质可能会导致有益的全谷物摄入减少,这可能会影响心血管风险,在无乳糜泻的患者中不鼓励无麸质饮食。

原始出处:

Benjamin Lebwohl,et al. Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study. BMJ 2017; http://www.bmj.com/content/357/bmj.j1892

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    2017-10-19 gaoxiaoe
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    2017-05-08 微笑人参

    粗粮,多元,维生素

    0

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    2017-05-06 1dd7d1dam20(暂无匿称)

    学习了有用。

    0

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    2017-05-05 jyzxjiangqin

    冠心病风险因素。

    0

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    2017-05-04 杨利洪

    学习了,我增加了知识

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1770997, encodeId=76f51e70997a5, content=<a href='/topic/show?id=5572308336a' target=_blank style='color:#2F92EE;'>#冠心病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30833, encryptionId=5572308336a, topicName=冠心病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc938196115, createdName=hbwxf, createdTime=Mon Mar 12 19:51:00 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848297, encodeId=cdb3184829e67, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Oct 19 20:51:00 CST 2017, time=2017-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195359, encodeId=7e55195359f3, content=粗粮,多元,维生素, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Mon May 08 10:33:20 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194617, encodeId=ffd319461e8a, content=学习了有用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da3d1626631, createdName=1dd7d1dam20(暂无匿称), createdTime=Sat May 06 14:56:54 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556655, encodeId=798b15566555f, content=<a href='/topic/show?id=0ba710300941' target=_blank style='color:#2F92EE;'>#麸质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103009, encryptionId=0ba710300941, topicName=麸质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6da14820260, createdName=nian.wang1987, createdTime=Fri May 05 23:51:00 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193990, encodeId=d3861939901a, content=冠心病风险因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri May 05 07:12:54 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193724, encodeId=691c193e24e0, content=学习了,我增加了知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Thu May 04 15:15:53 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193639, encodeId=c2ae193639b1, content=学习了谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Thu May 04 10:05:05 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193622, encodeId=7ffb19362230, content=学习,感谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Thu May 04 08:57:50 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 186****0580(小山羊)

    学习了谢谢了。

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1770997, encodeId=76f51e70997a5, content=<a href='/topic/show?id=5572308336a' target=_blank style='color:#2F92EE;'>#冠心病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30833, encryptionId=5572308336a, topicName=冠心病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc938196115, createdName=hbwxf, createdTime=Mon Mar 12 19:51:00 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848297, encodeId=cdb3184829e67, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Oct 19 20:51:00 CST 2017, time=2017-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195359, encodeId=7e55195359f3, content=粗粮,多元,维生素, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Mon May 08 10:33:20 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194617, encodeId=ffd319461e8a, content=学习了有用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da3d1626631, createdName=1dd7d1dam20(暂无匿称), createdTime=Sat May 06 14:56:54 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556655, encodeId=798b15566555f, content=<a href='/topic/show?id=0ba710300941' target=_blank style='color:#2F92EE;'>#麸质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103009, encryptionId=0ba710300941, topicName=麸质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6da14820260, createdName=nian.wang1987, createdTime=Fri May 05 23:51:00 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193990, encodeId=d3861939901a, content=冠心病风险因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri May 05 07:12:54 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193724, encodeId=691c193e24e0, content=学习了,我增加了知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Thu May 04 15:15:53 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193639, encodeId=c2ae193639b1, content=学习了谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Thu May 04 10:05:05 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193622, encodeId=7ffb19362230, content=学习,感谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Thu May 04 08:57:50 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
    2017-05-04 执着追梦

    学习,感谢分享!

    0

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