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J Am Acad Dermatol:三种筛查工具有助于诊断银屑病性关节炎

2014-08-01 Elizabeth(编译) 睿医资讯

通常,银屑病发生于PsA前,医生需警惕银屑病患者发生关节炎的可能性。PsA获得充分治疗的时间越晚,患者发生不可逆的关节损伤及其他改变的可能性越大。医生需要一种高度敏感的问卷表以对患者进行筛查以对潜在PsA患者进行评估。新的研究指出,有三种筛查工具可帮助诊断银屑病性关节炎(PsA),保证患者可及时接受治疗。 来自华盛顿大学和西雅图瑞典医学中心的Philip J. Mease及其研究组评估了3种

通常,银屑病发生于PsA前,医生需警惕银屑病患者发生关节炎的可能性。PsA获得充分治疗的时间越晚,患者发生不可逆的关节损伤及其他改变的可能性越大。医生需要一种高度敏感的问卷表以对患者进行筛查以对潜在PsA患者进行评估。新的研究指出,有三种筛查工具可帮助诊断银屑病性关节炎(PsA),保证患者可及时接受治疗。

来自华盛顿大学和西雅图瑞典医学中心的Philip J. Mease及其研究组评估了3种可在诊室中应用的工具——银屑病和关节炎筛查问卷(Psoriasis and Arthritis Screening Questionnaire,PASQ)、银屑病流行病学筛查工具(Psoriasis Epidemiology Screening Tool,PEST)、多伦多PsA筛查表(Toronto PsA Screen,ToPAS)。研究显示,这3种筛查方法在分辨PsA和非PsA患者时都表现出良好的敏感性和特异性。

Dr. Mease及其同事对估算PsA患病率的PREPARE试验的数据进行了亚研究,重点关注了PREPARE试验中所使用的3种筛查问卷的效果。相关结果6月25日在线发表于《美国皮肤病学会期刊(Journal of the American Academy of Dermatology)》。

除筛查问卷外,患者还接受了风湿病学家的评估。研究者们通过比较两种方式获得诊断来评估问卷的准确性,并计算了其敏感性/特异性以及阳性/阴性预测值。

在949例银屑病患者中,风湿病学家诊断有285例(30%)患有临床PsA。

而使用PASQ、PEST和ToPAS问卷进行筛查,结果发现可能患有PsA的患者比例分别为45.1%、43.0%和42.9%。三者的敏感/特异度、阳性/阴性预测值如下:


研究所使用的3种筛查工具均有很好的效果。使用这3种工具可分辨出PsA可能性较高的患者,这提示需由风湿病学医师进一步对此类患者进行评估。还需注意的是,3种筛查工具的阴性预测值均较高,提示这3种方法可分辨出患PsA可能性较小的患者,这些患者无需进行进一步评估。

在筛查工具的选择方面,来自芝加哥西北大学费恩伯格医学院的Eric M. Ruderman认为,重要的是使用其中一种筛查手段,而不是顾虑哪种方法最好。审视本项研究评估的筛查工具,确定哪种方法最适合你的实践流程,然后开始应用。

也有专家表示,这3种筛查手段都不尽完美。很多银屑病患者因其他原因而具有关节或后背疼痛,这3种筛查方法的特异性都不足以鉴别这些疼痛。

但增强皮肤科医师对于这一情况的认识,常规合理使用这3种筛查工具或许是可以实现的,这也可尽早诊断并获得更好的预后。

原始出处:

Mease PJ1, Gladman DD2, Helliwell P3, Khraishi MM4, Fuiman J5, Bananis E5, Alvarez D5.Comparative performance of psoriatic arthritis screening tools in patients with psoriasis in European/North American dermatology clinics.J Am Acad Dermatol. 2014 Jun 25. pii: S0190-9622(14)01438-8. doi: 10.1016/j.jaad.2014.05.010. [Epub ahead of print]

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    2015-05-14 lishizhe
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    2014-08-03 lmm397

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