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ACS Appl Mater Interfaces:3D打印支架用于大块骨缺损的修复

2019-06-15 不详 网络

二维(2D)材料已经成为组织工程的一个新的有前景的研究课题,因为它们能够改变组织支架的表面特性,从而改善它们的生物相容性和细胞亲和力。已经广泛报道了多种2D材料,例如石墨烯和氧化石墨烯(GO),以增强细胞粘附和增殖。最近,由于其独特的机械和电化学特性,新出现的黑磷(BP)2D材料在生物医学应用中引起了关注。在这项研究中,我们研究了这两种2D材料对骨组织工程细胞成骨的协同作用。首先将BP包裹在带负电

二维(2D)材料已经成为组织工程的一个新的有前景的研究课题,因为它们能够改变组织支架的表面特性,从而改善它们的生物相容性和细胞亲和力。已经广泛报道了多种2D材料,例如石墨烯和氧化石墨烯(GO),以增强细胞粘附和增殖。最近,由于其独特的机械和电化学特性,新出现的黑磷(BP)2D材料在生物医学应用中引起了关注。在这项研究中,我们研究了这两种2D材料对骨组织工程细胞成骨的协同作用。

首先将BP包裹在带负电荷的GO纳米片中,然后将其一起吸附到带正电的聚(丙烯富马酸酯)三维(3D)支架上。由GO纳米片提供的增加的表面积将增强初始阶段的细胞附着。此外,包裹在GO层内的BP纳米片的缓慢氧化将产生磷酸盐的连续释放,磷酸盐是一种重要的成骨细胞分化促进剂,其设计用于刺激细胞骨生成朝向新骨形成。通过使用3D共聚焦成像,观察到细胞和BP纳米片之间的独特相互作用,包括拉伸的细胞形状和BP纳米片周围的细丝的发展,以及与仅包含2D材料之一的支架相比增加的细胞增殖。此外,3D支架的生物矿化以及细胞成骨标志物都在具有BP和GO纳米片的支架上进行了测量和改进。

所有这些结果表明2D BP和GO材料的掺入可以有效地和协同地刺激3D组织支架上的细胞增殖和成骨。

原始出处:

Liu X, Miller AL 2nd, et al., Two-Dimensional Black Phosphorus and Graphene Oxide Nanosheets Synergistically Enhance Cell Proliferation and Osteogenesis on 3D Printed Scaffolds. ACS Appl Mater Interfaces. 2019 Jun 14. doi: 10.1021/acsami.9b04121. 

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    2019-07-05 shanyongle
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    2019-06-17 yaanren
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    2019-06-17 lfcmxl
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