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Atherosclerosis：脂肪肝的逆转、体重的降低均与血清脂质和载脂蛋白的改变独立相关

2018-03-20 MedSci MedSci原创

BMI脂肪肝insulinresistanceLipid代谢综合征Non-alcoholicFattyliverdisease肥
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脂肪肝的逆转改善了脂质谱，独立于体重减轻

研究背景：脂肪肝的逆转是否能独立于身体质量指数改善心血管疾病的危险因素，目前并不确定。本研究的目的是测试脂肪肝的逆转是否与脂质谱成分的改善有关，并量化肝脂肪逆转的益处的大小。

研究方法：本研究共纳入36195例脂肪肝患者。在随访（随机平均时间为4.93年）过程中，脂肪肝的持续或逆转通过超声来检测。在基线和随访过程中，检测总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和载脂蛋白胆固醇等指标。采用回归模型在基线和随访过程中检验脂肪肝状态变化或体重指数变化与血脂浓度之间的相关性。

研究结果：患者平均年龄为36.3±6.6 and 39.8±8.7岁(男性和女性，分别)。7086例患者脂肪肝得到逆转，29109例患者脂肪肝状态依旧。脂肪肝逆转的这些患者中，体重改变为-3.2±4.3 kg（Mean+/-SD，BMI下降约1kg/m2）。脂肪肝疾病状态依旧的患者，体重改变为+0.5±- 3.5 kg。脂肪肝的逆转和BMI的降低都与脂质谱成分的改善独立相关。BMI降低1kg/m2与脂肪肝的逆转相关。

研究结论：脂肪肝的逆转改善了脂质谱，独立于体重减轻。

原始出处

Sung KC， Lee MY， Lee JY， et al. Resolution of fatty liver and weight loss： Independent associations with changes in serum lipids and apolipoproteins.Atherosclerosis， 2018， 03，18， 47-53 . doi： 10.1016/j.atherosclerosis.

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    2018-06-08 12498b37m72暂无昵称

    #Sclerosis#

    0

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    2018-03-22 wmr111

    #载脂蛋白#

    0

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    2018-03-22 lsndxfj

    #ROS#

    0

  4. 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createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Wed Mar 21 06:55:26 CST 2018, time=2018-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298131, encodeId=987429813176, content=值得点赞.更值得收藏!慢慢领会学习的.给点个赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Mar 20 21:45:09 CST 2018, time=2018-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298120, encodeId=f49729812046, content=研究背景:脂肪肝的逆转是否能独立于身体质量指数改善心血管疾病的危险因素.目前并不确定.本研究的目的是测试脂肪肝的逆转是否与脂质谱成分的改善有关.并量化肝脂肪逆转的益处的大小., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Mar 20 21:27:27 CST 2018, time=2018-03-20, status=1, ipAttribution=)]
    2018-03-22 juliusluan79

    #脂蛋白#

    0

  5. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Mar 20 21:27:27 CST 2018, time=2018-03-20, status=1, ipAttribution=)]
    2018-03-21 1ddf0692m34(暂无匿称)

    学习了.谢谢分享

    0

  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Mar 20 21:27:27 CST 2018, time=2018-03-20, status=1, ipAttribution=)]
    2018-03-21 飛歌

    不错学习了很有用

    0

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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Mar 21 07:51:58 CST 2018, time=2018-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298236, encodeId=6ac1298236ee, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Mar 21 07:15:36 CST 2018, time=2018-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298217, encodeId=0c4529821ebc, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Wed Mar 21 06:55:26 CST 2018, time=2018-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298131, encodeId=987429813176, content=值得点赞.更值得收藏!慢慢领会学习的.给点个赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Mar 20 21:45:09 CST 2018, time=2018-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298120, encodeId=f49729812046, content=研究背景:脂肪肝的逆转是否能独立于身体质量指数改善心血管疾病的危险因素.目前并不确定.本研究的目的是测试脂肪肝的逆转是否与脂质谱成分的改善有关.并量化肝脂肪逆转的益处的大小., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Mar 20 21:27:27 CST 2018, time=2018-03-20, status=1, ipAttribution=)]
    2018-03-21 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

  8. 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encryptionId=5a3b8441438, topicName=脂蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23ea3924919, createdName=juliusluan79, createdTime=Thu Mar 22 11:28:00 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298298, encodeId=099829829875, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Mar 21 08:17:43 CST 2018, time=2018-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298279, encodeId=ec332982e9c2, content=不错学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Mar 20 21:27:27 CST 2018, time=2018-03-20, status=1, ipAttribution=)]
    2018-03-21 yfjms

    学习

    0

  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Mar 20 21:27:27 CST 2018, time=2018-03-20, status=1, ipAttribution=)]
    2018-03-20 虈亣靌

    值得点赞.更值得收藏!慢慢领会学习的.给点个赞!

    0

  10. 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    2018-03-20 有备才能无患

    研究背景:脂肪肝的逆转是否能独立于身体质量指数改善心血管疾病的危险因素.目前并不确定.本研究的目的是测试脂肪肝的逆转是否与脂质谱成分的改善有关.并量化肝脂肪逆转的益处的大小.

    0

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