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南非的新冠病毒突变B.1.1529,会是大BOSS,还是普通感冒样?

2021-11-26 MedSci原创 MedSci原创

南非政府定于当地时间25日发布这种新毒株的相关声明。非洲疾病预防控制中心表示,目前正与南非卫生官员联系,以了解新毒株及其对人的影响。科研人员警告称,新毒株存在大量突变,可能会通过躲避人体防御机制带来新

南非政府定于当地时间25日发布这种新毒株的相关声明。非洲疾病预防控制中心表示,目前正与南非卫生官员联系,以了解新毒株及其对人的影响。科研人员警告称,新毒株存在大量突变,可能会通过躲避人体防御机制带来新一波疫情。

伦敦大学学院遗传学研究所所长Tom Peacock在一份发表的声明中说,南非和博茨瓦纳出现一种新冠病毒变体。这种名为B.1.1529的新变体带有异常多的突变。他说,新变体很可能是在一个免疫力低下新冠患者的感染程中演变出来的,可能是在一名未经治疗的艾滋病患者身上。B. 1.1529 变种,预计将被称为 Nu 菌株,于 11 月 11 日在非洲Botswana首次被发现。

南非国家传染病研究所在一份声明中说,南非已经检测到22起该变体。

为什么梅斯医学如此关注这种新型的突变呢?至少有以下一些原因:

1、B. 1.1529 变种是突变的集大成者

专家表示,这种新变种引起了南非的关注,对该变种的主要担忧是它具有大量突变。南非国家传染病研究所将于当地时间26日与世界卫生组织举行紧急会议。

(香港卫生署N501Y变异株)

(南非变异株的完整突变位点列表)

2、B.1.1529感染能力可能大幅度上升

看看南非最近几天的病例变化,几乎是线性上涨。

图片

3、delta病毒完全不敌B.1.1529

不仅如此,最令人担心的是delta病毒在这个新的突变面前,几乎不堪一击!

图片

南非卫生部国家实验室(NHSL)的数据可以看出,砖红色的Delta本来占主导地位,但是,在蓝色的B.1.1.529冲击下,几乎不堪一击!

目前在香港,以色列等多国都已发现了B.1.1.529,而且部分检测试验盒无法很好检测出来,这会导致这种突变株更大范围的传播。我们近期会关注全球各地的病例变化,如果病例突然上升的话,可能就是这种新型的NU毒株了。

此前,科学家认为,delta毒株已经持续占优势很久了,其它一些毒株在delta下都未流行开来。如果delta持续不变的话,到明年夏天,病毒就基本能被很好地控制住。但是,如果B.1.1.529,全面取代delta的话,有可能再次造成一次全球性大流行。新冠病毒对抗就更任重而道远。

4、B. 1.1529 变种未来是BOSS还是普通感冒,未来15天见分晓

当然,病毒突变多,是风险,但也可能是好事。因为过度突变的话,也可能减弱其毒性(致病性),这次大的进化,是变成大BOSS,还是向普通感冒迈进,就在未来15天左右可以见分晓了。

未来只要看南非的重症病人的数量和比例,就知道这种新型变种的厉害了!

 

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1924942, encodeId=ca7e1924942ea, content=<a href='/topic/show?id=51d359969ac' target=_blank style='color:#2F92EE;'>#普通感冒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59969, encryptionId=51d359969ac, topicName=普通感冒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754b42, createdName=Luyuxie_9, createdTime=Thu Apr 14 23:34:34 CST 2022, time=2022-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414466, encodeId=abcb141446697, content=<a href='/topic/show?id=8e95364321f' target=_blank style='color:#2F92EE;'>#南非#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36432, encryptionId=8e95364321f, topicName=南非)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=83403055912, createdName=hongbochen, createdTime=Sun Nov 28 09:34:34 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074672, encodeId=b59e10e4672ff, content=毒性减弱也你可能变成感冒吧?再怎么也是病毒性肺炎,感冒只是上呼吸道感染,两者应该区别很大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c372403063, createdName=1235b519m83暂无昵称, createdTime=Sun Nov 28 00:52:25 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074322, encodeId=9a1f10e4322df, content=这个可能是大BOSS,就麻烦了,估计这个冬天,全球再来一波, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Fri Nov 26 20:34:23 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074314, encodeId=4dc310e431421, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Nov 26 19:26:40 CST 2021, time=2021-11-26, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1924942, encodeId=ca7e1924942ea, content=<a href='/topic/show?id=51d359969ac' target=_blank style='color:#2F92EE;'>#普通感冒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59969, encryptionId=51d359969ac, topicName=普通感冒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754b42, createdName=Luyuxie_9, createdTime=Thu Apr 14 23:34:34 CST 2022, time=2022-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414466, encodeId=abcb141446697, content=<a href='/topic/show?id=8e95364321f' target=_blank style='color:#2F92EE;'>#南非#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36432, encryptionId=8e95364321f, topicName=南非)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=83403055912, createdName=hongbochen, createdTime=Sun Nov 28 09:34:34 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074672, encodeId=b59e10e4672ff, content=毒性减弱也你可能变成感冒吧?再怎么也是病毒性肺炎,感冒只是上呼吸道感染,两者应该区别很大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c372403063, createdName=1235b519m83暂无昵称, createdTime=Sun Nov 28 00:52:25 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074322, encodeId=9a1f10e4322df, content=这个可能是大BOSS,就麻烦了,估计这个冬天,全球再来一波, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Fri Nov 26 20:34:23 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074314, encodeId=4dc310e431421, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Nov 26 19:26:40 CST 2021, time=2021-11-26, status=1, ipAttribution=)]
    2021-11-28 hongbochen
  3. [GetPortalCommentsPageByObjectIdResponse(id=1924942, encodeId=ca7e1924942ea, content=<a href='/topic/show?id=51d359969ac' target=_blank style='color:#2F92EE;'>#普通感冒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59969, encryptionId=51d359969ac, topicName=普通感冒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754b42, createdName=Luyuxie_9, createdTime=Thu Apr 14 23:34:34 CST 2022, time=2022-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414466, encodeId=abcb141446697, content=<a href='/topic/show?id=8e95364321f' target=_blank style='color:#2F92EE;'>#南非#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36432, encryptionId=8e95364321f, topicName=南非)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=83403055912, createdName=hongbochen, createdTime=Sun Nov 28 09:34:34 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074672, encodeId=b59e10e4672ff, content=毒性减弱也你可能变成感冒吧?再怎么也是病毒性肺炎,感冒只是上呼吸道感染,两者应该区别很大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c372403063, createdName=1235b519m83暂无昵称, createdTime=Sun Nov 28 00:52:25 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074322, encodeId=9a1f10e4322df, content=这个可能是大BOSS,就麻烦了,估计这个冬天,全球再来一波, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Fri Nov 26 20:34:23 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074314, encodeId=4dc310e431421, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Nov 26 19:26:40 CST 2021, time=2021-11-26, status=1, ipAttribution=)]
    2021-11-28 1235b519m83暂无昵称

    毒性减弱也你可能变成感冒吧?再怎么也是病毒性肺炎,感冒只是上呼吸道感染,两者应该区别很大。

    0

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    2021-11-26 病毒猎手

    这个可能是大BOSS,就麻烦了,估计这个冬天,全球再来一波

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1924942, encodeId=ca7e1924942ea, content=<a href='/topic/show?id=51d359969ac' target=_blank style='color:#2F92EE;'>#普通感冒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59969, encryptionId=51d359969ac, topicName=普通感冒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754b42, createdName=Luyuxie_9, createdTime=Thu Apr 14 23:34:34 CST 2022, time=2022-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414466, encodeId=abcb141446697, content=<a href='/topic/show?id=8e95364321f' target=_blank style='color:#2F92EE;'>#南非#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36432, encryptionId=8e95364321f, topicName=南非)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=83403055912, createdName=hongbochen, createdTime=Sun Nov 28 09:34:34 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074672, encodeId=b59e10e4672ff, content=毒性减弱也你可能变成感冒吧?再怎么也是病毒性肺炎,感冒只是上呼吸道感染,两者应该区别很大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c372403063, createdName=1235b519m83暂无昵称, createdTime=Sun Nov 28 00:52:25 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074322, encodeId=9a1f10e4322df, content=这个可能是大BOSS,就麻烦了,估计这个冬天,全球再来一波, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Fri Nov 26 20:34:23 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074314, encodeId=4dc310e431421, content=认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Nov 26 19:26:40 CST 2021, time=2021-11-26, status=1, ipAttribution=)]
    2021-11-26 医鸣惊人

    认真学习了。

    0

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