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J Ethnopharmacol:肺炎清化汤通过NF-κB和p38 MAPK途径抑制巨噬细胞和中性粒细胞的浸润,发挥流感抗炎作用

2024-09-27 紫菀款冬 MedSci原创 发表于上海

评估肺炎清化汤(FYQHD)治疗流感病毒感染的潜在疗效,并阐明其潜在机制。

背景:肺炎清化汤(FYQHD)是上海中医药大学曙光医院研制的治疗呼吸道感染的方剂。经过二十多年的临床应用,该配方已得到改进,以提高其治疗社区获得性肺炎(CAP)的疗效。近日,FYQHD在病毒性肺炎治疗中的应用专利(ZL202310415239.4)成功获得授权。流感病毒感染是严重肺炎的重要诱因,但FYQHD在治疗流感中的作用尚不清楚。

该研究旨在评估FYQHD治疗流感病毒感染的潜在疗效,并阐明其潜在机制。

方法:通过生存评价和病理分析评价FYQHD对流感的保护作用。转录组学分析鉴定流感中受FYQHD影响的基因和途径。研究FYQHD对toll样受体(TLR) 7结联刺激巨噬细胞抗炎作用及分子机制。利用非靶向代谢组学方法鉴定小鼠血清中吸收的FYQHD的关键成分,并利用ELISA方法评估其中一些化合物在巨噬细胞中的抗炎活性。

结果:FYQHD主要通过其抗炎特性提高PR8感染小鼠的存活率并减少肺损伤。与PR8 + OSV + FYQHD组相比,PR8 + OSV + FYQHD组肺指数和器官损伤明显降低,提示FYQHD和OSV在治疗流感中具有潜在的互补治疗作用。FYQHD有效降低趋化因子的表达,从而降低肺部炎性单核/巨噬细胞和中性粒细胞的趋化性和浸润。FYQHD对巨噬细胞的抗炎作用是通过抑制NF-κB活化和p38磷酸化实现的。确定了FYQHD在小鼠血清中吸收的关键成分,其中部分成分如汉黄芩素、木犀草素、山奈酚和异鼠李素等对原代巨噬细胞具有抗炎作用。

结论:FYQHD显示出对流感的保护作用,并显示出作为辅助治疗剂的前景,特别是在与OSV等抗病毒药物联合使用时。FYQHD中有效的抗炎成分为进一步探索对抗流感的药物研究和开发提供了基础。

然而,该研究也有一定的局限性。虽然已经确定了FYQHD中被认为介导其抗炎作用的活性成分,但需要进一步的研究来阐明它们在感染过程中如何发挥其免疫调节作用

原始出处:

Wu X, Xu LR, Xu GH, et al. Fei-Yan-Qing-Hua decoction exerts an anti-inflammatory role during influenza by inhibiting the infiltration of macrophages and neutrophils through NF-κB and p38 MAPK pathways. J Ethnopharmacol. Published online September 19, 2024. doi:10.1016/j.jep.2024.118846

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    2024-10-08 ms2000002022721049 来自江苏省

    打错了,结果那里

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2229721, encodeId=98d92229e2160, content=打错了,结果那里, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3c09477304, createdName=ms2000002022721049, createdTime=Tue Oct 08 09:12:19 CST 2024, time=2024-10-08, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2227996, encodeId=38c6222e99610, content=<a href='/topic/show?id=8f275032126' target=_blank style='color:#2F92EE;'>#期刊论坛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50321, encryptionId=8f275032126, topicName=期刊论坛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=191e5177841, createdName=146edf9dm89暂无昵称, createdTime=Fri Sep 27 13:17:53 CST 2024, time=2024-09-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=2227995, encodeId=0fcf222e9951a, content=肺炎清化汤(FYQHD)是上海中医药大学曙光医院研制的治疗呼吸道感染的方剂。经过二十多年的临床应用,该配方已得到改进,以提高其治疗社区获得性肺炎(CAP)的疗效。, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=191e5177841, createdName=146edf9dm89暂无昵称, createdTime=Fri Sep 27 13:17:46 CST 2024, time=2024-09-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=2227979, encodeId=5f3e222e97938, content=<a href='/topic/show?id=67a7821250e' target=_blank style='color:#2F92EE;'>#肺损伤#</a> <a href='/topic/show?id=e2a54816ecc' target=_blank style='color:#2F92EE;'>#巨噬细胞#</a> <a href='/topic/show?id=2f2d65340dc' target=_blank style='color:#2F92EE;'>#流感病毒#</a> <a href='/topic/show?id=a3f355391dc' target=_blank style='color:#2F92EE;'>#抗炎反应#</a> <a href='/topic/show?id=2f16e785571' target=_blank style='color:#2F92EE;'>#细胞因子风暴#</a> <a href='/topic/show?id=607c11959e3b' target=_blank style='color:#2F92EE;'>#肺炎清化汤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48167, encryptionId=e2a54816ecc, topicName=巨噬细胞), TopicDto(id=55391, encryptionId=a3f355391dc, topicName=抗炎反应), TopicDto(id=65340, encryptionId=2f2d65340dc, topicName=流感病毒), TopicDto(id=77855, encryptionId=2f16e785571, topicName=细胞因子风暴), TopicDto(id=82125, encryptionId=67a7821250e, topicName=肺损伤), TopicDto(id=119597, encryptionId=607c11959e3b, topicName=肺炎清化汤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cade5395722, createdName=梅斯管理员, createdTime=Fri Sep 27 11:36:59 CST 2024, time=2024-09-27, status=1, ipAttribution=上海)]
    2024-09-27 146edf9dm89暂无昵称 来自广东省
  3. [GetPortalCommentsPageByObjectIdResponse(id=2229721, encodeId=98d92229e2160, content=打错了,结果那里, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3c09477304, createdName=ms2000002022721049, createdTime=Tue Oct 08 09:12:19 CST 2024, time=2024-10-08, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2227996, encodeId=38c6222e99610, content=<a href='/topic/show?id=8f275032126' target=_blank style='color:#2F92EE;'>#期刊论坛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50321, encryptionId=8f275032126, topicName=期刊论坛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=191e5177841, createdName=146edf9dm89暂无昵称, createdTime=Fri Sep 27 13:17:53 CST 2024, time=2024-09-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=2227995, encodeId=0fcf222e9951a, content=肺炎清化汤(FYQHD)是上海中医药大学曙光医院研制的治疗呼吸道感染的方剂。经过二十多年的临床应用,该配方已得到改进,以提高其治疗社区获得性肺炎(CAP)的疗效。, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=191e5177841, createdName=146edf9dm89暂无昵称, createdTime=Fri Sep 27 13:17:46 CST 2024, time=2024-09-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=2227979, encodeId=5f3e222e97938, content=<a href='/topic/show?id=67a7821250e' target=_blank style='color:#2F92EE;'>#肺损伤#</a> <a href='/topic/show?id=e2a54816ecc' target=_blank style='color:#2F92EE;'>#巨噬细胞#</a> <a href='/topic/show?id=2f2d65340dc' target=_blank style='color:#2F92EE;'>#流感病毒#</a> <a href='/topic/show?id=a3f355391dc' target=_blank style='color:#2F92EE;'>#抗炎反应#</a> <a href='/topic/show?id=2f16e785571' target=_blank style='color:#2F92EE;'>#细胞因子风暴#</a> <a href='/topic/show?id=607c11959e3b' target=_blank style='color:#2F92EE;'>#肺炎清化汤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48167, encryptionId=e2a54816ecc, topicName=巨噬细胞), TopicDto(id=55391, encryptionId=a3f355391dc, topicName=抗炎反应), TopicDto(id=65340, encryptionId=2f2d65340dc, topicName=流感病毒), TopicDto(id=77855, encryptionId=2f16e785571, topicName=细胞因子风暴), TopicDto(id=82125, encryptionId=67a7821250e, topicName=肺损伤), TopicDto(id=119597, encryptionId=607c11959e3b, topicName=肺炎清化汤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cade5395722, createdName=梅斯管理员, createdTime=Fri Sep 27 11:36:59 CST 2024, time=2024-09-27, status=1, ipAttribution=上海)]
    2024-09-27 146edf9dm89暂无昵称 来自广东省

    肺炎清化汤(FYQHD)是上海中医药大学曙光医院研制的治疗呼吸道感染的方剂。经过二十多年的临床应用,该配方已得到改进,以提高其治疗社区获得性肺炎(CAP)的疗效。

    0

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