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JAMA子刊:别小瞧贫血,或可导致听力损失!

2017-01-09 生物探索 生物探索

导读:听力损伤或许是由缺铁性贫血所导致,来自宾夕法尼亚州立大学医学院的Kathleen M. Schieffer领导的研究团队详细地探究了缺铁性贫血与听力损失的关系。该研究发表于JAMA Otolaryngology - Head & Neck Surgery杂志上。在美国,约有15%的成年人都受到一定程度的听力损失的影响。其中,三分之二以上的成年人超过65岁,80%的成年人超过85岁。听

导读:听力损伤或许是由缺铁性贫血所导致,来自宾夕法尼亚州立大学医学院的Kathleen M. Schieffer领导的研究团队详细地探究了缺铁性贫血与听力损失的关系。该研究发表于JAMA Otolaryngology - Head & Neck Surgery杂志上。



在美国,约有15%的成年人都受到一定程度的听力损失的影响。其中,三分之二以上的成年人超过65岁,80%的成年人超过85岁。听力损失与健康状况不佳,高血压,吸烟,糖尿病和住院密切相关。


由于听力损失可能对个人健康产生重大影响,并且病因尚不明确,因此科学家们正在探索新的风险因素。比如,在突发性感音神经性听力损失(SNHL)中,患者听力在72小时内严重减少,最近研究表明该病与缺铁性贫血(IDA)相关。来自宾夕法尼亚州立大学医学院的Kathleen M. Schieffer领导的研究团队详细地探究了IDA与听力损失的关系。该研究发表于JAMA Otolaryngology - Head & Neck Surgery杂志上。

缺铁性贫血和听力损失

IDA是由身体缺铁引起的常见病症,其导致红细胞数目减少。由于红细胞负责在机体中运送氧气,因此IDA减少了可被组织利用的氧气含量。在全世界范围内,IDA影响着数亿人,其中美国的IDA患者估计有500万人。

研究团队使用来自Hershey医疗中心的电子医疗记录的数据。总共调查了来自305,339名21-90岁的成年人的数据,其中43%是男性,平均年龄为50岁。通过观察铁蛋白和血红蛋白水平,回顾性诊断IDA。

同时,研究团队还收集了有关患者听力的信息。他们分别查看传导性耳聋——由内耳骨骼问题导致,或SNHL——由耳蜗或内耳到大脑的神经通路损伤导致,耳聋和未指明的听力损失。通过分析数据,研究小组发现,SNHL和综合听力损失(SNHL和同一患者的传导性耳聋)都与IDA显着相关。

贫血如何影响听力?

为何IDA与听力损失相关?这其中的具体机制科学家尚未完全了解,但是存在一些可能的途径。比如,血液经由迷路动脉供应到内耳,这一过程对缺血性损伤(由血流量减少引起的损伤)高度敏感。因此可能成为贫血影响听力的原因之一。此外,具有血管疾病的人群更容易受患突发性SNHL。因此,血液供应显然是听力损失的一个重要因素。

另一种可能的机制涉及到髓磷脂,髓磷脂时一种附着在神经上的蜡质物质,它对于神经纤维的信号传导效率至关重要。体内缺铁引起脂质饱和酶及去饱和酶的降解,这两者在能量生产及髓磷脂的合成过程中十分重要。如果髓鞘包裹听神经的过程受损,听力可能降低。

研究小组的下一步计划将是观察铁补充是否可能积极干预听力损失。如果它确实可以改善受损的听力或减少听力损失,那么,这将可能成为一种既划算又有效的治疗方式。

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    2017-01-20 往日如昨

    保护好自己的听力很重要

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=171642, encodeId=14ed1e164252, content=保护好自己的听力很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Fri Jan 20 19:05:10 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171641, encodeId=351f1e164129, content=收藏了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Fri Jan 20 19:04:45 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171640, encodeId=061b1e164041, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Fri Jan 20 19:04:13 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171639, encodeId=bed01e163955, content=继续学习中, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Fri Jan 20 19:04:02 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1306046, encodeId=0d331306046cf, content=<a href='/topic/show?id=aeb639230b7' target=_blank style='color:#2F92EE;'>#听力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39230, encryptionId=aeb639230b7, topicName=听力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Wed Jan 11 05:32:00 CST 2017, time=2017-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=169335, encodeId=29cd1693356c, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Tue Jan 10 13:00:44 CST 2017, time=2017-01-10, status=1, ipAttribution=)]
    2017-01-20 往日如昨

    收藏了,谢谢分享

    0

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    2017-01-20 往日如昨

    受益匪浅

    0

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    2017-01-20 往日如昨

    继续学习中

    0

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    2017-01-11 ysjykql
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    2017-01-10 Jackie Li

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