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Diabetes Care:远端对称性多发性神经病与高血糖有关

2016-03-12 fsy 译 MedSci原创

以往的研究表明,代谢综合征与远端对称性多发性神经病(DSP)相关。该研究的目的是确定的这种影响的大小和所涉及的确切组分。在健康,衰老身体成分研究(前瞻性队列研究,参与者基线年龄70-79岁)中,研究人员确定了症状性DSP的患病率,由血糖状态(葡萄糖耐量试验)和额外的代谢综合征组分数量(更新国家胆固醇教育计划成人治疗组III的定义)进行分层。DSP通过神经性症状(问卷)加上三个确定测试的至少一种(重

以往的研究表明,代谢综合征与远端对称性多发性神经病(DSP)相关。该研究的目的是确定的这种影响的大小和所涉及的确切因素。

在健康、衰老身体成分研究(前瞻性队列研究,参与者基线年龄70-79岁)中,研究人员确定了症状性DSP的患病率,由血糖状态(葡萄糖耐量试验)和额外的代谢综合征组分数量(更新国家胆固醇教育计划成人治疗组III的定义)进行分层。DSP通过神经性症状(问卷)加上三个确定测试的至少一种(重单丝、腓传导速度和振动阈值)被定义。在横截面和纵向分析中,多变量逻辑和线性回归评估了代谢综合征组件和DSP的关联。

在进行神经检测的2382名参与者中(平均年龄73.5±2.9岁,38.2%为黑人,51.7%为女性),21.0%患有糖尿病,29.9%为糖尿病前期,52.8%有代谢综合征,11.1%为DSP患者。由血糖状态分层,DSP患病增加了代谢综合征部件的数量(P=0.03)。糖尿病(横截面模型,比值比[OR]1.65[95%CI1.18-2.31])和基线糖化血红蛋白(纵向模型,OR 1.42[95%CI1.15-1.75])是唯一的代谢综合征措施,与DSP显著相关。腰围和HDL与多发性继发性神经病变结果显著相关。

独立的血糖状况,症状性DSP在那些有额外的代谢综合征组分的患者中更为常见。然而,促使该关联的代谢综合症部分的问题,除了高血糖,仍不清楚。腰围大,低HDL可能与DSP有关,但还需要有更精确的代谢措施、更大规模的研究来证实。

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1759644, encodeId=8b2f1e596443c, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Sep 25 07:18:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901355, encodeId=2c74190135512, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jul 01 12:18:00 CST 2016, time=2016-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637288, encodeId=7da5163e28838, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Mar 25 09:18:00 CST 2016, time=2016-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709204, encodeId=c0421e092049d, content=<a href='/topic/show?id=dd2f43108e4' target=_blank style='color:#2F92EE;'>#多发性神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43108, encryptionId=dd2f43108e4, topicName=多发性神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=849831619609, createdName=ms3892185887221420, createdTime=Sat May 14 14:18:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261078, encodeId=e5e712610e81e, content=<a href='/topic/show?id=30c6102e2607' target=_blank style='color:#2F92EE;'>#高血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102726, encryptionId=30c6102e2607, topicName=高血糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Mar 14 13:18:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491236, encodeId=fd6d14912361b, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Mon Mar 14 13:18:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1889662, encodeId=0992188966284, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Thu Nov 10 14:18:00 CST 2016, time=2016-11-10, status=1, ipAttribution=)]
    2016-03-14 hbwxf
  6. [GetPortalCommentsPageByObjectIdResponse(id=1759644, encodeId=8b2f1e596443c, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Sep 25 07:18:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901355, encodeId=2c74190135512, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jul 01 12:18:00 CST 2016, time=2016-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637288, encodeId=7da5163e28838, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Mar 25 09:18:00 CST 2016, time=2016-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709204, encodeId=c0421e092049d, content=<a href='/topic/show?id=dd2f43108e4' target=_blank style='color:#2F92EE;'>#多发性神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43108, encryptionId=dd2f43108e4, topicName=多发性神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=849831619609, createdName=ms3892185887221420, createdTime=Sat May 14 14:18:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261078, encodeId=e5e712610e81e, content=<a href='/topic/show?id=30c6102e2607' target=_blank style='color:#2F92EE;'>#高血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102726, encryptionId=30c6102e2607, topicName=高血糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Mar 14 13:18:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491236, encodeId=fd6d14912361b, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Mon Mar 14 13:18:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1889662, encodeId=0992188966284, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Thu Nov 10 14:18:00 CST 2016, time=2016-11-10, status=1, ipAttribution=)]
    2016-03-14 axin012
  7. [GetPortalCommentsPageByObjectIdResponse(id=1759644, encodeId=8b2f1e596443c, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Sep 25 07:18:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901355, encodeId=2c74190135512, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jul 01 12:18:00 CST 2016, time=2016-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637288, encodeId=7da5163e28838, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Mar 25 09:18:00 CST 2016, time=2016-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709204, encodeId=c0421e092049d, content=<a href='/topic/show?id=dd2f43108e4' target=_blank style='color:#2F92EE;'>#多发性神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43108, encryptionId=dd2f43108e4, topicName=多发性神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=849831619609, createdName=ms3892185887221420, createdTime=Sat May 14 14:18:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261078, encodeId=e5e712610e81e, content=<a href='/topic/show?id=30c6102e2607' target=_blank style='color:#2F92EE;'>#高血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102726, encryptionId=30c6102e2607, topicName=高血糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Mar 14 13:18:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491236, encodeId=fd6d14912361b, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Mon Mar 14 13:18:00 CST 2016, time=2016-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1889662, encodeId=0992188966284, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Thu Nov 10 14:18:00 CST 2016, time=2016-11-10, status=1, ipAttribution=)]
    2016-11-10 jml2009
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