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npj Breast Cancer:中国城市高危女性的乳腺癌风险因素和乳房密度|

2018-03-26 佚名 Nature自然科研

乳房摄影密度(MD)的升高毫无疑问是患乳腺癌的一大风险因素。在中国,关于MD与乳腺癌风险因素相互关系的研究尚属不多。目前虽然已经确定的一些乳腺癌危险因素在中国还不太普遍,但是,乳房摄影密度的升高却比西方国家发生的更为普遍。

乳房摄影密度(MD)的升高毫无疑问是患乳腺癌的一大风险因素。在中国,关于MD与乳腺癌风险因素相互关系的研究尚属不多。目前虽然已经确定的一些乳腺癌危险因素在中国还不太普遍,但是,乳房摄影密度的升高却比西方国家发生的更为普遍。

在自然合作期刊npj Breast Cancer最近发表的研究Breast cancer risk factors and mammographic density among high-risk women in urban China中,中国医学科学院北京协和医学院Min Dai、Jie He与美国NIH的Xiaohong R. Yang 带领的研究团队观察了11478位女性(45-69岁; 36%处于绝经前期),她们正参与在中国11个城市省份中进行的全国癌症筛查计划,并被预测具有较高的患乳腺癌的风险。

研究者采用多元逻辑回归分析,将较高的BI-RADS(乳房影像报告和数据系统)类别(第2类、第3类或第4类)与最低类别(第 1类BI-RADS)进行比较,评估了MD和风险因素之间的关联。研究者发现,年龄升高、体重指数、体重、绝经后状态以及平等状态与较低的MD相关,并且这些关联并不受绝经状态的影响。

此外,研究者只在绝经后妇女中观察到了较长时间的母乳喂养与较低的MD相互关联(P交互作用= 0.003)。如果绝经前妇女有直系亲属在50岁以前就被诊断出乳腺癌的话,那么她可能会具有较低的MD(P交互作用= 0.061)。研究者还发现,一些确定的乳腺癌风险因素对MD的效应在中国和西方妇女中呈现出比较类似的方向,从而佐证了MD代表生命过程中累积接触乳腺癌危险因素的假设。研究者表示,他们的研究结果有助于了解MD与乳腺癌风险因素之间相互关系的生物学基础,并对中国的乳腺癌预防研究具有借鉴意义。 



从中国乳腺癌筛查计划(2013-2014)中挑选高危女性进行乳房X线筛查和纳入密度评估的过程示意图。

原始出处:
Hyuna Sung, Jiansong Ren, Jing Li, et al. Breast cancer risk factors and mammographic density among high-risk women in urban China. npj Breast Cancer. Feb, 2018.

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    2018-03-28 zhaojie88
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    2018-03-27 186****0580(小山羊)

    学习了谢谢了

    0

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    2018-03-27 changjiu

    学习一下谢谢

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2061727, encodeId=991c2061e274f, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Thu Aug 23 10:51:00 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711425, encodeId=a8931e1142546, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Sep 28 15:51:00 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770295, encodeId=66601e702955a, content=<a href='/topic/show?id=df9c23e868a' target=_blank style='color:#2F92EE;'>#乳腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23786, encryptionId=df9c23e868a, topicName=乳腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9538161180, createdName=gaoxiaoe, createdTime=Mon Feb 11 12:51:00 CST 2019, time=2019-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351103, encodeId=f51913511035c, content=<a href='/topic/show?id=12e43e1263' target=_blank style='color:#2F92EE;'>#Breast#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3712, encryptionId=12e43e1263, topicName=Breast)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Mar 28 12:51:00 CST 2018, time=2018-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300176, encodeId=d8ed3001e6ac, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Tue Mar 27 10:12:43 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300059, encodeId=a8533000592d, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue Mar 27 06:11:55 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299989, encodeId=10fc299989be, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon Mar 26 22:31:24 CST 2018, time=2018-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299983, encodeId=36782999837d, content=^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Mon Mar 26 22:06:34 CST 2018, time=2018-03-26, status=1, ipAttribution=)]
    2018-03-26 1e1b8538m79(暂无匿称)

    不错的文章值得拥有

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2061727, encodeId=991c2061e274f, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Thu Aug 23 10:51:00 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711425, encodeId=a8931e1142546, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Sep 28 15:51:00 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770295, encodeId=66601e702955a, content=<a href='/topic/show?id=df9c23e868a' target=_blank style='color:#2F92EE;'>#乳腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23786, encryptionId=df9c23e868a, topicName=乳腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9538161180, createdName=gaoxiaoe, createdTime=Mon Feb 11 12:51:00 CST 2019, time=2019-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351103, encodeId=f51913511035c, content=<a href='/topic/show?id=12e43e1263' target=_blank style='color:#2F92EE;'>#Breast#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3712, encryptionId=12e43e1263, topicName=Breast)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Mar 28 12:51:00 CST 2018, time=2018-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300176, encodeId=d8ed3001e6ac, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Tue Mar 27 10:12:43 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300059, encodeId=a8533000592d, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue Mar 27 06:11:55 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299989, encodeId=10fc299989be, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon Mar 26 22:31:24 CST 2018, time=2018-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299983, encodeId=36782999837d, content=^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Mon Mar 26 22:06:34 CST 2018, time=2018-03-26, status=1, ipAttribution=)]
    2018-03-26 wqkm

    ^_^^_^^_^

    0

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