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喜欢高糖、高脂、高热量?不是我,是基因

2015-11-12 佚名 生物谷

你是否发现自己无法抵抗高脂高糖美食的诱惑?看到这类食物就会流口水,拔不动腿?科学家们发现你的基因可能要为此负责。   最近在洛杉矶举行的一个学术会议上,来自伦敦帝国学院的研究人员介绍了他们的一项最新研究成果,他们发现了一对基因突变能够影响脑部对高脂以及含糖食物的奖赏效应,他们认为这些发现或可帮助开发新的肥胖治疗方法。   新发现的这两个基因突变位于FTO基因


你是否发现自己无法抵抗高脂高糖美食的诱惑?看到这类食物就会流口水,拔不动腿?科学家们发现你的基因可能要为此负责。
 
最近在洛杉矶举行的一个学术会议上,来自伦敦帝国学院的研究人员介绍了他们的一项最新研究成果,他们发现了一对基因突变能够影响脑部对高脂以及含糖食物的奖赏效应,他们认为这些发现或可帮助开发新的肥胖治疗方法。
 
新发现的这两个基因突变位于FTO基因和DRD2基因附近,之前许多研究已经证实FTO基因与肥胖发生风险增加有关。
 
在该项研究中,研究人员对所有参与者的DNA进行了分析,随后他们给参与者看了高卡路里或低卡路里食物的图片,并使用MRI方法对他们的脑部应答情况进行了观察。同时他们还要求参与者给能够吸引他们的食物图片进行排名。

领导该项研究的Dr. Tony Goldstone表示,他们首次发现携带FTO基因变异的个体在看到高卡路里食物时,他们的大脑纹状体活性会增强,但是这同时还依赖于他们携带了哪种DRD2基因变异体,DRD2基因变异会改变脑部多巴胺系统的活性。
 
这些发现表明携带FTO突变的人更容易发生肥胖的一个原因可能是他们在面对高脂高糖食物时,脑部的多巴胺信号促进了他们对食物的欲望,导致他们吃得更多。
 
Goldstone表示携带这些特定基因变异的人可能会对常规的肥胖治疗方法产生不同应答。
 
这项研究的结果能够帮助科学家们更好地理解一些人存在肥胖发生倾向性的生物学基础,进而根据病人携带的不同基因突变开发靶向治疗方法,帮助病人提高治疗效率,甚至是开发个体化肥胖治疗方法。
 

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    2015-11-14 pcw111
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    2015-11-13 高山2012

    注意节制

    0

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    2015-11-13 KO229256262

    不怪别人,也怪不得自己,都是基因惹得祸

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1574554, encodeId=328f15e455417, content=<a href='/topic/show?id=9b56102616bb' target=_blank style='color:#2F92EE;'>#高脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102616, encryptionId=9b56102616bb, topicName=高脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b716021149, createdName=pcw111, createdTime=Sat Nov 14 02:07:00 CST 2015, time=2015-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1613826, encodeId=07421613826aa, content=<a href='/topic/show?id=d87e6e25687' target=_blank style='color:#2F92EE;'>#热量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67256, encryptionId=d87e6e25687, topicName=热量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Nov 14 02:07:00 CST 2015, time=2015-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43104, encodeId=3de84310414, content=注意节制, beContent=null, objectType=article, channel=null, level=null, likeNumber=168, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a1571654784, createdName=高山2012, createdTime=Fri Nov 13 09:13:00 CST 2015, time=2015-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43100, encodeId=05ae4310006, content=不怪别人,也怪不得自己,都是基因惹得祸, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/17/3872cad7a53dc9dcbd08202fb6313cf4.jpg, createdBy=2cb71609450, createdName=KO229256262, createdTime=Fri Nov 13 09:07:00 CST 2015, time=2015-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43083, encodeId=eaeb430837b, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=3e4e1656579, createdName=1dddc5edm75(暂无匿称), createdTime=Fri Nov 13 00:00:00 CST 2015, time=2015-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43082, encodeId=b141430828c, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Thu Nov 12 23:59:00 CST 2015, time=2015-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43075, encodeId=6a6c430e503, content=要注意日常生活, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7b5d1660826, createdName=crystal 丁, createdTime=Thu Nov 12 23:11:00 CST 2015, time=2015-11-12, status=1, ipAttribution=)]
    2015-11-12 sanshengshi

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1574554, encodeId=328f15e455417, content=<a href='/topic/show?id=9b56102616bb' target=_blank style='color:#2F92EE;'>#高脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102616, encryptionId=9b56102616bb, topicName=高脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b716021149, createdName=pcw111, createdTime=Sat Nov 14 02:07:00 CST 2015, time=2015-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1613826, encodeId=07421613826aa, content=<a href='/topic/show?id=d87e6e25687' target=_blank style='color:#2F92EE;'>#热量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67256, encryptionId=d87e6e25687, topicName=热量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Nov 14 02:07:00 CST 2015, time=2015-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43104, encodeId=3de84310414, content=注意节制, beContent=null, objectType=article, channel=null, level=null, likeNumber=168, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a1571654784, createdName=高山2012, createdTime=Fri Nov 13 09:13:00 CST 2015, time=2015-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43100, encodeId=05ae4310006, content=不怪别人,也怪不得自己,都是基因惹得祸, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/17/3872cad7a53dc9dcbd08202fb6313cf4.jpg, createdBy=2cb71609450, createdName=KO229256262, createdTime=Fri Nov 13 09:07:00 CST 2015, time=2015-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43083, encodeId=eaeb430837b, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=3e4e1656579, createdName=1dddc5edm75(暂无匿称), createdTime=Fri Nov 13 00:00:00 CST 2015, time=2015-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43082, encodeId=b141430828c, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Thu Nov 12 23:59:00 CST 2015, time=2015-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43075, encodeId=6a6c430e503, content=要注意日常生活, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7b5d1660826, createdName=crystal 丁, createdTime=Thu Nov 12 23:11:00 CST 2015, time=2015-11-12, status=1, ipAttribution=)]
    2015-11-12 crystal 丁

    要注意日常生活

    0

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