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Am J Clin Nutr:脂肪组织中ALA含量与胰岛素抵抗呈负相关

2016-03-07 Mechront 译 MedSci原创

有研究表明,n-3 (ω-3)脂肪酸(FAs) 对心血管代谢危险因素有益,但是脂肪组织α-亚麻酸(ALA)、二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)与胰岛素抵抗间的联系仍未知。因此研究者对健康成年人进行了一项横断面研究,使用多因素分析探究脂肪组织n-3 FAs (总n-3 FAs、ALA、EPA+DHA)与胰岛素抵抗间的联系。AHS-2队列中所有成年参与者(716人,平均年龄58岁)通过稳

有研究表明,n-3 (ω-3)脂肪酸(FAs) 对心血管代谢危险因素有益,但是脂肪组织α-亚麻酸(ALA)、二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)与胰岛素抵抗间的联系仍未知。

因此研究者对健康成年人进行了一项横断面研究,使用多因素分析探究脂肪组织n-3 FAs (总n-3 FAs、ALA、EPA+DHA)与胰岛素抵抗间的联系。AHS-2队列中所有成年参与者(716人,平均年龄58岁)通过稳态模型评估胰岛素抵抗(HOMA-IR)情况。

研究数据显示,与最低三分之一组相比,脂肪组织ALA最高组与HOMA-IR呈负相关(β = -0.13; 95% CI: -0.24, -0.01)。通过腰围进行分层分析后,女性腰围≤88 cm组或男性腰围≤102 cm组中,ALA仍与HOMA-IR呈负相关[最高三分之一组:β = -0.17 (95% CI: -0.31, -0.02)];但是在更大腰围组,没有发现这种关系。研究者也没有观察到脂肪组织EPA+DHA与HOMA-IR间的关系。

研究结果显示,成年男女性脂肪组织中更高含量的ALA与胰岛素抵抗呈负相关,尤其是腰围在正常范围的个体。

原始出处:


Heskey CE, Jaceldo-Siegl K,et al.Adipose tissue α-linolenic acid is inversely associated with insulin resistance in adults.Am J Clin Nutr. 2016 Feb 24. pii: ajcn118935. 


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    2016-10-05 baoya
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    2016-03-09 hmwwww

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